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Cbl [cytosol]
Stable Identifier
R-RNO-112199
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
CBL, A0A8I6G3R2
Locations in the PathwayBrowser
Expand all
Immune System (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
Signaling by Interleukins (Rattus norvegicus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Rattus norvegicus)
Regulation of signaling by CBL (Rattus norvegicus)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
Interleukin-6 family signaling (Rattus norvegicus)
Interleukin-6 signaling (Rattus norvegicus)
PTPN11 binds CBL (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11:CBL [plasma membrane] (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Signaling by Non-Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by PTK6 (Rattus norvegicus)
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 (Rattus norvegicus)
PTK6 phosphorylates CBL (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by EGFR (Rattus norvegicus)
EGFR downregulation (Rattus norvegicus)
Binding of CBL to EGFR (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
CBL binds and ubiquitinates phosphorylated Sprouty (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
CBL binds to GRB2 (Rattus norvegicus)
CBL:GRB2 [cytosol] (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Rattus norvegicus)
CBL:GRB2 [cytosol] (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
CBL ubiquitinates Sprouty (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:CBL:p-Y53/55-SPRY1/2 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
CBL-mediated ubiquitination of CIN85 (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
CDC42:GTP binds CBL:Beta-Pix (Rattus norvegicus)
CBL:Beta-Pix:CDC42:GTP [cytosol] (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
Localization of CBL:GRB2 to the membrane (Rattus norvegicus)
CBL:GRB2 [cytosol] (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Rattus norvegicus)
CBL:GRB2 [cytosol] (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
Phosphorylation of CBL (EGFR:CBL) (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
Phosphorylation of CBL (EGFR:GRB2:CBL) (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Rattus norvegicus)
CBL:GRB2 [cytosol] (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
Sprouty lures CBL away from EGFR (Rattus norvegicus)
CBL:SPRY1/2 [cytosol] (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
Signaling by FGFR (Rattus norvegicus)
Signaling by FGFR1 (Rattus norvegicus)
Negative regulation of FGFR1 signaling (Rattus norvegicus)
Spry regulation of FGF signaling (Rattus norvegicus)
CBL dissociates from ubiquitinated p-SPRY2 (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
Phosphorylated SPRY2 is ubiquitinated by CBL (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
SPRY2 binds CBL (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
Signaling by FGFR2 (Rattus norvegicus)
Negative regulation of FGFR2 signaling (Rattus norvegicus)
Spry regulation of FGF signaling (Rattus norvegicus)
CBL dissociates from ubiquitinated p-SPRY2 (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
Phosphorylated SPRY2 is ubiquitinated by CBL (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
SPRY2 binds CBL (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
Signaling by FGFR3 (Rattus norvegicus)
Negative regulation of FGFR3 signaling (Rattus norvegicus)
Spry regulation of FGF signaling (Rattus norvegicus)
CBL dissociates from ubiquitinated p-SPRY2 (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
Phosphorylated SPRY2 is ubiquitinated by CBL (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
SPRY2 binds CBL (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
Signaling by FGFR4 (Rattus norvegicus)
Negative regulation of FGFR4 signaling (Rattus norvegicus)
Spry regulation of FGF signaling (Rattus norvegicus)
CBL dissociates from ubiquitinated p-SPRY2 (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
Phosphorylated SPRY2 is ubiquitinated by CBL (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
SPRY2 binds CBL (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
Signaling by MET (Rattus norvegicus)
Negative regulation of MET activity (Rattus norvegicus)
CBL binds MET (Rattus norvegicus)
CBL:GRB2,CBL [cytosol] (Rattus norvegicus)
CBL:GRB2 [cytosol] (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
HGF:p-4Y-MET dimer:GRB2:CBL,(HGF:p-Y1003,4Y-MET dimer:CBL) [plasma membrane] (Rattus norvegicus)
HGF:p-4Y-MET dimer:GRB2:CBL [plasma membrane] (Rattus norvegicus)
CBL:GRB2 [cytosol] (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
HGF:p-Y1003,4Y-MET dimer:CBL [plasma membrane] (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
MET phosphorylates CBL (Rattus norvegicus)
HGF:p-4Y-MET dimer:GRB2:CBL,(HGF:p-Y1003,4Y-MET dimer:CBL) [plasma membrane] (Rattus norvegicus)
HGF:p-4Y-MET dimer:GRB2:CBL [plasma membrane] (Rattus norvegicus)
CBL:GRB2 [cytosol] (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
HGF:p-Y1003,4Y-MET dimer:CBL [plasma membrane] (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
Signaling by SCF-KIT (Rattus norvegicus)
Regulation of KIT signaling (Rattus norvegicus)
Recruitment of CBL to KIT (Rattus norvegicus)
CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
Signaling by TGFB family members (Rattus norvegicus)
Signaling by TGF-beta Receptor Complex (Rattus norvegicus)
TGF-beta receptor signaling activates SMADs (Rattus norvegicus)
CBL binds TGFBR2 (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
TGFBR2:CBL [plasma membrane] (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
CBL neddylates TGFBR2 (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
TGFBR2:CBL [plasma membrane] (Rattus norvegicus)
Cbl [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:A0A8I6G3R2
Gene Names
Cbl
Reference Genes
BioGPS Gene:500985 Cbl
ENSEMBL:ENSRNOG00000008444
KEGG:rno:500985 Cbl
Monarch:500985 Cbl
NCBI Gene:500985 Cbl
UCSC:A0A8I6G3R2 Cbl
Reference Transcript
RefSeq:NM_001419955.1 Cbl
Other Identifiers
10916669
1375732_at
1379603_at
1380069_at
1388505_at
17851655
500985
5702805
5745570
5754160
5781549
5792349
5854693
5866567
5896756
5987519
5997178
6028351
6032770
6116936
6123006
6146275
6276154
6284360
6381871
6449529
6516931
6545637
6710864
A_44_P214797
A_64_P009325
GE1111203
GE17577
GO:0001784
GO:0003824
GO:0004842
GO:0005509
GO:0005515
GO:0005794
GO:0005829
GO:0005886
GO:0005929
GO:0006511
GO:0007166
GO:0016567
GO:0016600
GO:0016740
GO:0017124
GO:0023051
GO:0032487
GO:0042059
GO:0043066
GO:0043226
GO:0046872
GO:0046875
GO:0048260
GO:0051897
GO:0061630
GO:0070086
GO:0140096
GO:2000583
ILMN_1355687
PH_rn_0001767
PH_rn_0021361
rc_AI178321_at
Participates
as a candidate of
CBL:GRB2,CBL [cytosol] (Rattus norvegicus)
as a component of
HGF:p-Y1003,4Y-MET dimer:CBL [plasma membrane] (Rattus norvegicus)
CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Rattus norvegicus)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11:CBL [plasma membrane] (Rattus norvegicus)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Rattus norvegicus)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Rattus norvegicus)
CBL:Beta-Pix:CDC42:GTP [cytosol] (Rattus norvegicus)
CBL:SPRY1/2 [cytosol] (Rattus norvegicus)
CBL:GRB2 [cytosol] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Rattus norvegicus)
TGFBR2:CBL [plasma membrane] (Rattus norvegicus)
as an input of
Recruitment of CBL to KIT (Rattus norvegicus)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Rattus norvegicus)
PTPN11 binds CBL (Rattus norvegicus)
SPRY2 binds CBL (Rattus norvegicus)
CDC42:GTP binds CBL:Beta-Pix (Rattus norvegicus)
Sprouty lures CBL away from EGFR (Rattus norvegicus)
CBL binds to GRB2 (Rattus norvegicus)
Binding of CBL to EGFR (Rattus norvegicus)
PTK6 phosphorylates CBL (Rattus norvegicus)
CBL binds TGFBR2 (Rattus norvegicus)
as an output of
CBL dissociates from ubiquitinated p-SPRY2 (Rattus norvegicus)
CBL neddylates TGFBR2 (Rattus norvegicus)
Other forms of this molecule
phospho-Cbl [cytosol]
phospho-Cbl [cytosol]
phospho-Cbl [plasma membrane]
phospho-Cbl [cytosol]
phospho-Cbl [cytosol]
Inferred From
CBL [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001406884.1
ENSEMBL
ENSRNOT00000101607
,
ENSRNOP00000079790
,
ENSRNOG00000008444
RGD
1561386
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