Reactome | RPA3 [nucleoplasm]

RPA3 [nucleoplasm]

Stable Identifier

R-PFA-68459

Type

Protein [EntityWithAccessionedSequence]

Species

Plasmodium falciparum

Compartment

nucleoplasm

Synonyms

C6S3I6

Locations in the PathwayBrowser

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DNA Repair (Plasmodium falciparum)

- DNA Damage Bypass (Plasmodium falciparum)
  - Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Plasmodium falciparum)
    - Translesion Synthesis by POLH (Plasmodium falciparum)
      - SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Plasmodium falciparum)
        
        NPLOC4:UFD1L:VCP:SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Plasmodium falciparum)
        
        SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Plasmodium falciparum)
        
        POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Plasmodium falciparum)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Plasmodium falciparum)
        
        RPA heterotrimer [nucleoplasm] (Plasmodium falciparum)
        
        RPA3 [nucleoplasm] (Plasmodium falciparum)
        
        SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Plasmodium falciparum)
        
        POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Plasmodium falciparum)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Plasmodium falciparum)
        
        RPA heterotrimer [nucleoplasm] (Plasmodium falciparum)
        
        RPA3 [nucleoplasm] (Plasmodium falciparum)
    - Translesion synthesis by POLI (Plasmodium falciparum)
      - POLI incorporates dNMP opposite to damaged DNA base (Plasmodium falciparum)
        
        POLI:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:(EtAD:T)-DNA Template,(Gamma-HOPdG:C)-DNA Template [nucleoplasm] (Plasmodium falciparum)
        
        MonoUb:K164-PCNA:RPA:RFC:(EtAD:T)-DNA Template,(Gamma-HOPdG:C)-DNA Template [nucleoplasm] (Plasmodium falciparum)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Plasmodium falciparum)
        
        RPA heterotrimer [nucleoplasm] (Plasmodium falciparum)
        
        RPA3 [nucleoplasm] (Plasmodium falciparum)
        
        POLI:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:EtAD-DNA Template,Gamma-HOPdG-DNA Template [nucleoplasm] (Plasmodium falciparum)
        
        MonoUb:K164-PCNA:RPA:RFC:EtAD-DNA Template,Gamma-HOPdG-DNA Template [nucleoplasm] (Plasmodium falciparum)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Plasmodium falciparum)
        
        RPA heterotrimer [nucleoplasm] (Plasmodium falciparum)
        
        RPA3 [nucleoplasm] (Plasmodium falciparum)
    - Translesion synthesis by POLK (Plasmodium falciparum)
      - POLK incorporates dNMP opposite to damaged DNA base (Plasmodium falciparum)
        
        POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:(Tg:A)-DNA Template,(OGUA:A)-DNA Template,(BPDE-G:C)-DNA Template [nucleoplasm] (Plasmodium falciparum)
        
        MonoUb:K164-PCNA:RPA:RFC:(Tg:A)-DNA Template,(OGUA:A)-DNA Template,(BPDE-G:C)-DNA Template [nucleoplasm] (Plasmodium falciparum)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Plasmodium falciparum)
        
        RPA heterotrimer [nucleoplasm] (Plasmodium falciparum)
        
        RPA3 [nucleoplasm] (Plasmodium falciparum)
        
        POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:Tg-DNA Template,OGUA-DNA Template,BPDE-G-DNA Template [nucleoplasm] (Plasmodium falciparum)
        
        MonoUb:K164-PCNA:RPA:RFC:Tg-DNA Template,OGUA-DNA Template,BPDE-G-DNA Template [nucleoplasm] (Plasmodium falciparum)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Plasmodium falciparum)
        
        RPA heterotrimer [nucleoplasm] (Plasmodium falciparum)
        
        RPA3 [nucleoplasm] (Plasmodium falciparum)
    - Translesion synthesis by REV1 (Plasmodium falciparum)
      - POLZ extends translesion synthesis (Plasmodium falciparum)
        
        POLZ:REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-DNA Template [nucleoplasm] (Plasmodium falciparum)
        
        REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-DNA Template [nucleoplasm] (Plasmodium falciparum)
        
        MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-dsDNA [nucleoplasm] (Plasmodium falciparum)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Plasmodium falciparum)
        
        RPA heterotrimer [nucleoplasm] (Plasmodium falciparum)
        
        RPA3 [nucleoplasm] (Plasmodium falciparum)
        
        REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt-mispairedPolydNMP)-DNA Template [nucleoplasm] (Plasmodium falciparum)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Plasmodium falciparum)
        
        RPA heterotrimer [nucleoplasm] (Plasmodium falciparum)
        
        RPA3 [nucleoplasm] (Plasmodium falciparum)
      - REV1 binds AP-dsDNA (Plasmodium falciparum)
        
        MonoUb:K164-PCNA:RPA:RFC:AP-DNA Template [nucleoplasm] (Plasmodium falciparum)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Plasmodium falciparum)
        
        RPA heterotrimer [nucleoplasm] (Plasmodium falciparum)
        
        RPA3 [nucleoplasm] (Plasmodium falciparum)
        
        REV1:MonoUb:K164-PCNA:RPA:RFC:AP-DNA Template [nucleoplasm] (Plasmodium falciparum)
        
        MonoUb:K164-PCNA:RPA:RFC:AP-DNA Template [nucleoplasm] (Plasmodium falciparum)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Plasmodium falciparum)
        
        RPA heterotrimer [nucleoplasm] (Plasmodium falciparum)
        
        RPA3 [nucleoplasm] (Plasmodium falciparum)
      - REV1 inserts dCMP opposite to AP sites in DNA (Plasmodium falciparum)
        
        REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-DNA Template [nucleoplasm] (Plasmodium falciparum)
        
        MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-dsDNA [nucleoplasm] (Plasmodium falciparum)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Plasmodium falciparum)
        
        RPA heterotrimer [nucleoplasm] (Plasmodium falciparum)
        
        RPA3 [nucleoplasm] (Plasmodium falciparum)
        
        REV1:MonoUb:K164-PCNA:RPA:RFC:AP-DNA Template [nucleoplasm] (Plasmodium falciparum)
        
        MonoUb:K164-PCNA:RPA:RFC:AP-DNA Template [nucleoplasm] (Plasmodium falciparum)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Plasmodium falciparum)
        
        RPA heterotrimer [nucleoplasm] (Plasmodium falciparum)
        
        RPA3 [nucleoplasm] (Plasmodium falciparum)
      - REV1 recruits POLZ to (AP:Cyt)-DNA Template (Plasmodium falciparum)
        
        POLZ:REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-DNA Template [nucleoplasm] (Plasmodium falciparum)
        
        REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-DNA Template [nucleoplasm] (Plasmodium falciparum)
        
        MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-dsDNA [nucleoplasm] (Plasmodium falciparum)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Plasmodium falciparum)
        
        RPA heterotrimer [nucleoplasm] (Plasmodium falciparum)
        
        RPA3 [nucleoplasm] (Plasmodium falciparum)
        
        REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-DNA Template [nucleoplasm] (Plasmodium falciparum)
        
        MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-dsDNA [nucleoplasm] (Plasmodium falciparum)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Plasmodium falciparum)
        
        RPA heterotrimer [nucleoplasm] (Plasmodium falciparum)
        
        RPA3 [nucleoplasm] (Plasmodium falciparum)
- Nucleotide Excision Repair (Plasmodium falciparum)
  - Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Plasmodium falciparum)
    - Dual incision in TC-NER (Plasmodium falciparum)
      - 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Plasmodium falciparum)
        
        TC-NER incision complex [nucleoplasm] (Plasmodium falciparum)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Plasmodium falciparum)
        
        RPA heterotrimer [nucleoplasm] (Plasmodium falciparum)
        
        RPA3 [nucleoplasm] (Plasmodium falciparum)
        
        TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Plasmodium falciparum)
        
        RPA heterotrimer [nucleoplasm] (Plasmodium falciparum)
        
        RPA3 [nucleoplasm] (Plasmodium falciparum)
      - DNA polymerases delta, epsilon or kappa bind the TC-NER site (Plasmodium falciparum)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Plasmodium falciparum)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Plasmodium falciparum)
        
        RPA heterotrimer [nucleoplasm] (Plasmodium falciparum)
        
        RPA3 [nucleoplasm] (Plasmodium falciparum)
        
        TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Plasmodium falciparum)
        
        RPA heterotrimer [nucleoplasm] (Plasmodium falciparum)
        
        RPA3 [nucleoplasm] (Plasmodium falciparum)
    - Gap-filling DNA repair synthesis and ligation in TC-NER (Plasmodium falciparum)
      - Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Plasmodium falciparum)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Plasmodium falciparum)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Plasmodium falciparum)
        
        RPA heterotrimer [nucleoplasm] (Plasmodium falciparum)
        
        RPA3 [nucleoplasm] (Plasmodium falciparum)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Plasmodium falciparum)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Plasmodium falciparum)
        
        RPA heterotrimer [nucleoplasm] (Plasmodium falciparum)
        
        RPA3 [nucleoplasm] (Plasmodium falciparum)

External Reference Information

External Reference

UniProt:C6S3I6

Reference Genes

BioGPS Gene:8444955

ENSEMBL:PF3D7_1442100

KEGG:pfa:PF3D7_1442100

Monarch:8444955

NCBI Gene:8444955

PlasmoDB:PF3D7_1442100

UCSC:C6S3I6

Reference Transcript

RefSeq:XM_002585416.1

Participates

as a component of

RPA heterotrimer [nucleoplasm] (Plasmodium falciparum)

Inferred From

RPA3 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_002585462.1

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