Formation of the chimeric human-bovine immunoproteasome

Stable Identifier
R-NUL-9908700
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
3/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Formation of the chimeric human-bovine immunoproteasome
Based on a study using the human PA28-alpha-beta heteroheptamer and bovine 20S immunoproteasome core particle (20S iCP) for in vitro assembly of the chimeric immunoproteasome and the subsequent cryogenic electron microscopy-based structural analysis (cryo-EM), in the final step of immunoproteasome assembly, the PA28-alpha-beta regulatory particle binds to the 20S immunoproteasome core particle (20S iCP) through interaction between PSME1 and PSME2 subunits of the PA28-alpha-beta heteroheptamer and the alpha (PSMA) subunits of the outer ring of the 20S iCP (Chen et al. 2021).
Literature References
PubMed ID Title Journal Year
33531497 Cryo-EM of mammalian PA28αβ-iCP immunoproteasome reveals a distinct mechanism of proteasome activation by PA28αβ

Chen, J, Wang, Y, Xu, C, Chen, K, Zhao, Q, Wang, S, Yin, Y, Peng, C, Ding, Z, Cong, Y

Nat Commun 2021
Participants
Input
Output
Orthologous Events
Formation of the immunoproteasome (Homo sapiens)
Authored
Orlic-Milacic, M  (2024-04-22)
Created
Orlic-Milacic, M  (2024-04-22)
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