Mutyh cleaves adenine mispaired with 8-oxoguanine

Stable Identifier
R-NUL-9635966
Type
Reaction [transition]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Mutyh cleaves adenine mispaired with 8-oxoguanine
Wild-type mouse Mutyh removes adenine mispaired with 8-oxoguanine from damaged DNA (Yanaru-Fujisawa et al. 2008).
Literature References
PubMed ID Title Journal Year
18422726 Genomic and functional analyses of MUTYH in Japanese patients with adenomatous polyposis

Yanaru-Fujisawa, R, Matsumoto, T, Ushijima, Y, Esaki, M, Hirahashi, M, Gushima, M, Yao, T, Nakabeppu, Y, Iida, M

Clin. Genet. 2008
Participants
Input
Output
Catalyst Activity

DNA N-glycosylase activity of Mutyh:(OGUA:Ade)-dsDNA [nucleoplasm]

Physical Entity
Mutyh:(OGUA:Ade)-dsDNA [nucleoplasm] (Mus musculus)
Activity
DNA N-glycosylase activity (GO:0019104)
Authored
Orlic-Milacic, M  (2018-05-12)
Reviewed
Nakabeppu, Y  (2018-06-28)
Created
Orlic-Milacic, M  (2019-02-11)
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