BDNF- or NTF4-activated Ntrk2 phosphorylates Plcg1

Stable Identifier
R-NUL-9030450
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
BDNF- or NTF4-activated Ntrk2 phosphorylates Plcg1
Recombinant rat Ntrk2 (TrkB), activated by recombinant human BDNF or recombinant human NTF4 (NT-4) phosphorylates mouse Plcg1 (PLCgamma1) (Yuen and Mobley 1999). While not all Plcg1 phosphorylation sites downstream of Ntrk2 have been examined, they are assumed based on the accepted model of Plcg1 activation (Carpenter and Ji 1999).
Literature References
PubMed ID Title Journal Year
10486198 Early BDNF, NT-3, and NT-4 signaling events

Yuen, EC, Mobley, WC

Exp. Neurol. 1999
Participants
Input
Output
Catalyst Activity

protein tyrosine kinase activity of BDNF,NTF4:p-5Y-Ntrk2:Plcg1 [plasma membrane]

Physical Entity
BDNF,NTF4:p-5Y-Ntrk2:Plcg1 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
NTRK2 phosphorylates PLCG1 (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-01-05)
Reviewed
Castrén, E  (2018-02-13)
Antila, H  (2018-02-13)
Created
Orlic-Milacic, M  (2017-11-28)
Cite Us!