Hes5 gene expression is stimulated by Notch3

Stable Identifier
R-NUL-9013728
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Hes5 gene expression is stimulated by Notch3
A recombinant mouse Notch3 intracellular domain (NICD3), likely in complex with Rbpj and Maml (Maml1, Maml2 or Maml3), positively regulates transcription from the mouse Hes5 gene promoter (Shimizu et al. 2002, Lin et al. 2002).
Literature References
PubMed ID Title Journal Year
11866432 Functional diversity among Notch1, Notch2, and Notch3 receptors

Shimizu, K, Chiba, S, Saito, T, Kumano, K, Hamada, Y, Hirai, H

Biochem Biophys Res Commun 2002
12386158 Identification of new human mastermind proteins defines a family that consists of positive regulators for notch signaling

Lin, SE, Oyama, T, Nagase, T, Harigaya, K, Kitagawa, M

J. Biol. Chem. 2002
Participants
Input
Output
This event is regulated
Positively by
Regulator
Notch3 coactivator complex [nucleoplasm] (Homo sapiens)
Orthologous Events
HES5 gene expression is stimulated by NOTCH3 (Homo sapiens)
Authored
Orlic-Milacic, M  (2017-09-20)
Reviewed
Haw, R  (2017-10-30)
Created
Orlic-Milacic, M  (2017-07-25)
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