Tpl2 phosphorylates Mek1, Sek1

Stable Identifier
R-NUL-451681
Type
Reaction [transition]
Species
Mus musculus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Tpl2 phosphorylates Mek1, Sek1
Tpl2 (also known as Cot, officially known as MAP3K8) is constitutively bound to NFKB p105 (p105) which inhibits its MEK kinase activity in resting cells. Proteolysis of p105 frees Tpl2 from p105 and allows subsequent phosphorylation and activation of MEK1. Tpl2 can also activate SEK1 (MAP2K4). Phosphorylation of Tpl-2 is believed to play a role in its activation (Cho et al, 2005; Robinson et al. 2007).
Positions of phosphorylations represented here are inferred from general experimental data (Zheng & Guan, 1994).
Literature References
PubMed ID Title Journal Year
8631303 Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinase

Salmeron, A, Ahmad, TB, Carlile, GW, Pappin, D, Narsimhan, RP, Ley, SC

EMBO J 1996
Participants
Input
Output
Catalyst Activity

MAP kinase kinase kinase activity of Tpl2 [cytosol]

Physical Entity
Tpl2 [cytosol] (Rattus norvegicus)
Activity
MAP kinase kinase kinase activity (GO:0004709)
Orthologous Events
TPL2 phosphorylates MEK1, SEK1 (Homo sapiens)
Authored
Ray, KP  (2010-05-17)
Reviewed
Pinteaux, E  (2010-05-17)
Created
Jupe, S  (2010-01-08)
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