G alpha (i) inhibits adenylate cyclase

Stable Identifier
R-NUL-421821
Type
Reaction [binding]
Species
Canis familiaris
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
G alpha (i) inhibits adenylate cyclase
G-proteins in the Gi class inhibit adenylate cyclase activity, decreasing the production of cAMP from ATP, which has many consequences but classically results in decreased activity of Protein Kinase A (PKA). cAMP also activates the cyclic nucleotide-gated ion channels, a process that is particularly important in olfactory cells. Experimental data for this reaction was obtained in vitro using rat G alpha (i) and dog Adenylate Cyclase.
Literature References
PubMed ID Title Journal Year
8327893 Inhibition of adenylyl cyclase by Gi alpha

Taussig, R, Iñiguez-Lluhi, JA, Gilman, AG

Science 1993
8119955 Distinct patterns of bidirectional regulation of mammalian adenylyl cyclases

Taussig, R, Tang, WJ, Hepler, JR, Gilman, AG

J Biol Chem 1994
Participants
Input
Output
Orthologous Events
G alpha (i) inhibits adenylate cyclase (Homo sapiens)
Authored
Jupe, S  (2009-05-21)
Reviewed
Akkerman, JW  (2009-06-03)
Created
Jupe, S  (2009-05-21)
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