G alpha (i) inhibits adenylate cyclase

Stable Identifier
R-NUL-421821
Type
Reaction [binding]
Species
Canis familiaris
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
G alpha (i) inhibits adenylate cyclase
G-proteins in the Gi class inhibit adenylate cyclase activity, decreasing the production of cAMP from ATP, which has many consequences but classically results in decreased activity of Protein Kinase A (PKA). cAMP also activates the cyclic nucleotide-gated ion channels, a process that is particularly important in olfactory cells. Experimental data for this reaction was obtained in vitro using rat G alpha (i) and dog Adenylate Cyclase.
Literature References
PubMed ID Title Journal Year
8327893 Inhibition of adenylyl cyclase by Gi alpha

Taussig, R, IƱiguez-Lluhi, JA, Gilman, AG

Science 1993
8119955 Distinct patterns of bidirectional regulation of mammalian adenylyl cyclases

Taussig, R, Tang, WJ, Hepler, JR, Gilman, AG

J Biol Chem 1994
Participants
Orthologous Events
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