NCAM1 binds FGFR-1

Stable Identifier
R-NUL-420393
Type
Reaction [binding]
Species
Mus musculus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
NCAM1 binds FGFR-1
FGFR is one of the heterophilic interactors of NCAM. The FG loop region of the second Fn3 module of NCAM binds to Ig domains 2 and 3 of FGFR. The FGFR binding site to NCAM overlaps with the site of NCAM-ATP interaction, and ATP is capable of disrupting NCAM-FGFR binding and signaling.
The interaction of NCAM activates FGFR and NCAM might merely mimic FGF's in FGFR stimulation, but there is a difference in the activation pattern induced by NCAM and FGF-2. NCAM activated FGFR stimulates neurite outgrowth by stimulating PLCgamma and DAG lipase leading to generation of arachidonic acid.
Literature References
PubMed ID Title Journal Year
12791257 Structural basis for a direct interaction between FGFR1 and NCAM and evidence for a regulatory role of ATP

Kiselyov, VV, Skladchikova, G, Hinsby, AM, Jensen, PH, Kulahin, N, Soroka, V, Pedersen, N, Tsetlin, V, Poulsen, FM, Berezin, V, Bock, E

Structure 2003
16045455 Structural biology of NCAM homophilic binding and activation of FGFR

Kiselyov, VV, Soroka, V, Berezin, V, Bock, E

J Neurochem 2005
Participants
Input
Output
Orthologous Events
NCAM1 binds FGFR-1 (Homo sapiens)
Authored
Garapati, P V  (2009-02-24)
Reviewed
Maness, PF  (2009-05-26)
Walmod, PS  (2009-05-26)
Created
Garapati, P V  (2009-05-11)
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