Collagen type I binds integrin alpha1beta1, alpha2beta1, alpha10beta1

Stable Identifier
R-NUL-4084908
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Collagen type I binds integrin alpha1beta1, alpha2beta1, alpha10beta1
Integrin alpha1beta1 binds to collagen type IV and VI with higher affinity than to types I-III, whereas alpha2beta1 has a higher affinity for collagen types I-III than for type IV. Integrin alpha10beta1 binds collagen types I, IV, and VI with similar affinities (Tulla et al. 2001). Integrin alpha11beta1 binds preferentially to the fibril-forming collagen types I and II, binding to type III is weaker and collagens IV and VI are poor ligands (Zhang et al. 2003).
Literature References
PubMed ID Title Journal Year
11518510 alpha11beta1 integrin is a receptor for interstitial collagens involved in cell migration and collagen reorganization on mesenchymal nonmuscle cells

Tiger, CF, Fougerousse, F, Grundstrom, G, Velling, T, Gullberg, D

Dev Biol 2001
11572855 Selective binding of collagen subtypes by integrin alpha 1I, alpha 2I, and alpha 10I domains

Tulla, M, Pentikäinen, OT, Viitasalo, T, Käpylä, J, Impola, U, Nykvist, P, Nissinen, L, Johnson, MS, Heino, J

J. Biol. Chem. 2001
Participants
Input
Output
Orthologous Events
Collagen type I binds integrin alpha1beta1, alpha2beta1, alpha10beta1 (Homo sapiens)
Authored
Jupe, S  (2012-08-08)
Reviewed
Ricard-Blum, S  (2013-08-13)
Created
Jupe, S  (2013-08-01)
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