Syndecan-2 binds Trappc4

Stable Identifier
R-NUL-2750175
Type
Reaction [binding]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Syndecan-2 binds Trappc4

Syndecans have attached heparan sulfate (HS) and to a lesser extent chondroitin sulfate (CS) chains. These allow interactions with a large number of proteins. Various enzymes involved in post-translational HS chain modifications produce unique binding motifs that selectively recognize different proteins (Tkachenko et al. 2005). Syndecan-null mice have subtle phenotypes when compared with mice deficient in HS chain synthesis or modification (Echtermeyer et al. 2001, Ishiquro et al. 2001, Götte et al. 2002). GPI-anchored glypicans and matrix HSPGs such as perlecan may compensate for the absence of syndecans. Syndecans are also signalling molecules, interacting with cytoplasmic proteins. Syndecan-2 binds Trafficking protein particle complex subunit 4 (TRAPPC4), also known as synbindin. It appears to be involved with postsynaptic membrane trafficking (Ethell et al. 2000). Syndecan-2 expression promotes dendritic spine maturation in neurons, and requires the C2 domain (Ethell et al. 2000), suggesting that syndecan-2 and synbindin recruit intracellular vesicles to postsynaptic sites. More recently TRAPPC4 was shown to be a component of the Transport Protein Particle, involved in endoplasmic reticulum-to-Golgi transport (Fan et al. 2009).

Literature References
PubMed ID Title Journal Year
11018053 Synbindin, A novel syndecan-2-binding protein in neuronal dendritic spines

Ethell, IM, Hagihara, K, Miura, Y, Irie, F, Yamaguchi, Y

J. Cell Biol. 2000
Participants
Orthologous Events
Authored
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