Syndecan-1 binds integrin alphaVbeta3

Stable Identifier
R-NUL-2731085
Type
Reaction [binding]
Species
Homo sapiens
Compartment
General
SVG |   | PPTX  | SBGN
Syndecan-1 binds integrin alphaVbeta3

Syndecans have attached heparan sulfate (HS) and to a lesser extent chondroitin sulfate (CS) chains. These allow interactions with a large number of proteins. Various enzymes involved in post-translational HS chain modifications produce unique binding motifs that selectively recognize different proteins (Tkachenko et al. 2005). It is thought that syndecans often act in concert with other receptors, e.g. alphavbeta3 and alphavbeta5 integrins cooperate with syndecan-1 during adhesion to vitronectin (Beauvais et al. 2004, McQuade et al. 2006). The relationship between syndecans and co-receptors is not well understood (Alexopoulou et al. 2007). Syndecan-null mice have subtle phenotypes when compared with mice deficient in HS chain synthesis or modification (Echtermeyer et al. 2001, Ishiquro et al. 2001, Götte et al. 2002).

Literature References
PubMed ID Title Journal Year
15479743 The syndecan-1 ectodomain regulates alphavbeta3 integrin activity in human mammary carcinoma cells

Beauvais, DM, Burbach, BJ, Rapraeger, AC

J. Cell Biol. 2004
Participants
Orthologous Events
Authored
Reviewed
Created
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