Nid1 degradation by MMP14, MMP15

Stable Identifier
R-NUL-2533964
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Nid1 degradation by MMP14, MMP15
Nidogen-1 (entactin) is a member of the nidogen family of basement membrane glycoproteins. It interacts with several other components of basement membranes, notably it connects the collagen and laminin networks to each other (Yurchenko & Patton 2009). The membrane-associated MMPs 14 and 15 (d'Ortho et al. 1997) can degrade nidogen-1.
Literature References
PubMed ID Title Journal Year
9461298 Membrane-type matrix metalloproteinases 1 and 2 exhibit broad-spectrum proteolytic capacities comparable to many matrix metalloproteinases

d'Ortho, MP, Will, H, Atkinson, S, Butler, G, Messent, A, Gavrilovic, J, Smith, B, Timpl, R, Zardi, L, Murphy, G

Eur J Biochem 1997
Participants
Input
Output
Catalyst Activity

metalloendopeptidase activity of MMP14, MMP15 [plasma membrane]

Physical Entity
MMP14, MMP15 [plasma membrane] (Homo sapiens)
Activity
metalloendopeptidase activity (GO:0004222)
Orthologous Events
NID1 degradation by MMP14, MMP15 (Homo sapiens)
Authored
Jupe, S  (2012-08-08)
Reviewed
Ricard-Blum, S  (2013-08-13)
Created
Jupe, S  (2012-10-22)
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