Laminin-511 degradation by MMP14

Stable Identifier
R-NUL-2533890
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Laminin-511 degradation by MMP14
Laminins can be degraded by the membrane-associated metalloproteinase MMP14 (Ohuchi et al. 1997, Bair et al. 2005 Gutiérrez-Fernández et al. 2009). Cleavage of the alpha (Ohuchi et al. 1997, Bair et al. 2005) and beta chains (Udayakumar et al. 2003) by MMP14 has been demonstrated; gamma chain cleavage is considered likely as other MMPs are known to cleave this subunit.
Literature References
PubMed ID Title Journal Year
8999957 Membrane type 1 matrix metalloproteinase digests interstitial collagens and other extracellular matrix macromolecules

Ohuchi, E, Imai, K, Fujii, Y, Sato, H, Seiki, M, Okada, Y

J Biol Chem 1997
15967115 Membrane type 1 matrix metalloprotease cleaves laminin-10 and promotes prostate cancer cell migration

Bair, EL, Chen, ML, McDaniel, K, Sekiguchi, K, Cress, AE, Nagle, RB, Bowden, GT

Neoplasia 2005
Participants
Input
Output
Catalyst Activity

metalloendopeptidase activity of MMP14,TMPRSS6 [plasma membrane]

Physical Entity
MMP14,TMPRSS6 [plasma membrane] (Homo sapiens)
Activity
metalloendopeptidase activity (GO:0004222)
Orthologous Events
Laminin-511 degradation by MMP14 (Homo sapiens)
Authored
Jupe, S  (2012-08-08)
Reviewed
Ricard-Blum, S  (2013-08-13)
Created
Jupe, S  (2012-10-22)
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