Uchl5 deubiquitinates TGFBR1

Stable Identifier
R-NUL-2179313
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
ReviewStatus
5/5
General
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PNG
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Uchl5 deubiquitinates TGFBR1
Recombinant mouse Uchl5 (Uch37) exogenously expressed in HEK293 cells deubiquitinates recombinant human TGFBR1. This stabilizes TGFBR1 and prolongs signaling by TGF-beta receptor complex. Deubiqutination of Smad7 has not been examined in this context (Wicks et al. 2005).
Literature References
PubMed ID Title Journal Year
16027725 The deubiquitinating enzyme UCH37 interacts with Smads and regulates TGF-beta signalling

Wicks, SJ, Haros, K, Maillard, M, Song, L, Cohen, RE, Dijke, PT, Chantry, A

Oncogene 2005
Participants
Input
Output
Catalyst Activity

cysteine-type deubiquitinase activity of TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-Smad7:Uchl5 [plasma membrane]

Physical Entity
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-Smad7:Uchl5 [plasma membrane] (Homo sapiens)
Activity
cysteine-type deubiquitinase activity (GO:0004843)
Orthologous Events
UCHL5, USP15 deubiquitinate TGFBR1 (Homo sapiens)
Authored
Orlic-Milacic, M  (2012-04-05)
Reviewed
Huang, T  (2012-05-14)
Created
Orlic-Milacic, M  (2012-04-03)
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