DLL4 binds Notch4

Stable Identifier
R-NUL-2168986
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
DLL4 binds Notch4
Vascular endothelium of embryonic and adult mice strongly expresses Dll4 and Notch4. Dll4 was shown to activate Notch4 signaling in Xenopus embryos by co-injection of mouse Dll4 and Notch4 mRNAs (Shutter et al. 2000). When HMVECd cells (human primary endothelial cell line derived from neonatal dermal microvasculature) expressing recombinant mouse Notch4 are co-cultured with HMVECd cells expressing recombinant human DLL4 or mouse Dll4, NOTCH4 signaling is activated (Shawber et al. 2003, Shawber et al. 2007).
Literature References
PubMed ID Title Journal Year
10837024 Dll4, a novel Notch ligand expressed in arterial endothelium

Richards, WG, Fan, W, Scully, S, Kintner, CR, Shutter, JR, Stark, KL, Deblandre, GA, Kitajewski, J

Genes Dev 2000
17948123 Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression

Feirt, N, Vorontchikhina, M, Chawengsaksophak, K, Borisenko, V, Stowell, SA, Shiraishi, K, Shawber, CJ, Skobe, M, Kitajewski, J, Podgrabinska, S, Francisco, E, Kitamura, Y, Rossant, J, Accili, D, Funahashi, Y

J. Clin. Invest. 2007
12814948 Notch signaling in primary endothelial cells

Das, I, Shawber, CJ, Kitajewski, J, Francisco, E

Ann. N. Y. Acad. Sci. 2003
Participants
Orthologous Events
Authored
Reviewed
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