DLL4 binds Notch4

Stable Identifier
R-NUL-2168986
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
DLL4 binds Notch4

Vascular endothelium of embryonic and adult mice strongly expresses Dll4 and Notch4. Dll4 was shown to activate Notch4 signaling in Xenopus embryos by co-injection of mouse Dll4 and Notch4 mRNAs (Shutter et al. 2000). When HMVECd cells (human primary endothelial cell line derived from neonatal dermal microvasculature) expressing recombinant mouse Notch4 are co-cultured with HMVECd cells expressing recombinant human DLL4 or mouse Dll4, NOTCH4 signaling is activated (Shawber et al. 2003, Shawber et al. 2007).

Literature References
PubMed ID Title Journal Year
17948123 Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression

Shawber, CJ, Funahashi, Y, Francisco, E, Vorontchikhina, M, Kitamura, Y, Stowell, SA, Borisenko, V, Feirt, N, Podgrabinska, S, Shiraishi, K, Chawengsaksophak, K, Rossant, J, Accili, D, Skobe, M, Kitajewski, J

J. Clin. Invest. 2007
10837024 Dll4, a novel Notch ligand expressed in arterial endothelium

Shutter, JR, Scully, S, Fan, W, Richards, WG, Kitajewski, J, Deblandre, GA, Kintner, CR, Stark, KL

Genes Dev 2000
12814948 Notch signaling in primary endothelial cells

Shawber, CJ, Das, I, Francisco, E, Kitajewski, J

Ann. N. Y. Acad. Sci. 2003
Participants
Input
Output
Entity On Other Cell
Orthologous Events
DLL4 binds NOTCH4 (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-04-05)
Reviewed
Haw, R  (2018-05-01)
Created
Orlic-Milacic, M  (2012-03-26)
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