PI is phosphorylated to PI5P by Pikfyve at the late endosome membrane

Stable Identifier
R-NUL-1676051
Type
Reaction [transition]
Species
Mus musculus
Compartment
General
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PI is phosphorylated to PI5P by Pikfyve at the late endosome membrane

At the late endosome membrane, the PAS complex, consisting of mouse FYVE finger-containing phosphoinositide kinase (Pikfyve), yeast VAC14 homologue (VAC14), and polyphosphoinositide phosphatase aka SAC3 (FIG4), binds to the membrane via Pikfyve's FYVE finger. The Pikfyve kinase component phosphorylates phosphatidylinositol (PI) to phosphatidylinositol 5-phosphate (PI5P) (Sbrissa et al. 1999, Sbrissa et al. 2002). The PAS complex is present in the cytosol and is recruited to the membrane.

Literature References
PubMed ID Title Journal Year
12270933 Phosphatidylinositol 5-phosphate biosynthesis is linked to PIKfyve and is involved in osmotic response pathway in mammalian cells

Sbrissa, D, Ikonomov, OC, Deeb, R, Shisheva, A

J Biol Chem 2002
10419465 PIKfyve, a mammalian ortholog of yeast Fab1p lipid kinase, synthesizes 5-phosphoinositides. Effect of insulin

Sbrissa, D, Ikonomov, OC, Shisheva, A

J Biol Chem 1999
Participants
Catalyst Activity
Catalyst Activity
Title
1-phosphatidylinositol-5-kinase activity of Pikfyve:VAC14:FIG4 [late endosome membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created