Ivermectin binds importin

Stable Identifier
R-MMU-9954451
Type
Reaction [transition]
Species
Mus musculus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Ivermectin binds importin
Ivermectin is a macrocyclic drug that is approved against onchocerciasis and other parasitic diseases. It binds the alpha-subunit of the importin heterodimer (IMPα/β1). This binding, characterized in vitro using recombinant mouse importins, leads to the dissociation of the IMPα/β1 heterodimer and prevents IMPα from binding to IMPβ1. As a result, ivermectin blocks nuclear import, specifically of host and viral proteins that have a classical nuclear localization signal (cNLS) motif (Yang et al., 2020; reviewed in Jans & Wagstaff, 2020).
Literature References
PubMed ID Title Journal Year
32942671 Ivermectin as a Broad-Spectrum Host-Directed Antiviral: The Real Deal?

Jans, DA, Wagstaff, KM

Cells 2020
32135219 The broad spectrum antiviral ivermectin targets the host nuclear transport importin α/β1 heterodimer

Yang, SNY, Atkinson, SC, Wang, C, Lee, A, Bogoyevitch, MA, Borg, NA, Jans, DA

Antiviral Res 2020
Participants
Input
Output
Orthologous Events
Ivermectin binds importin (Homo sapiens)
Authored
Stephan, R  (2025-06-03)
Reviewed
Roque Ascenção, F  (2025-10-29)
Mansur, DS  (2025-10-29)
Created
Stephan, R  (2025-06-07)
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