Tbx21 and Runx3 bind the Il4 gene

Stable Identifier
R-MMU-9945888
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Tbx21 and Runx3 bind the Il4 gene
Tbx21 and Runx3 bind a silencer located about 2 kb downstream of the Il4 coding region (Djuretic et al. 2007, Naoe et al. 2007, Gökmen et al. 2013), causing repression of Il4 expression (Djuretic et al. 2007, Naoe et al. 2007, Zhuang et al. 2009, Zhu et al. 2012, Gökmen et al. 2013). Il4 is an activator of Th2 differentiation, therefore Tbx21 and Runx3 act to restrict differentiation to the Th1 cell type.
Literature References
PubMed ID Title Journal Year
17195845 Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells

Djuretic, IM, Levanon, D, Negreanu, V, Groner, Y, Rao, A, Ansel, KM

Nat Immunol 2007
17646405 Repression of interleukin-4 in T helper type 1 cells by Runx/Cbf beta binding to the Il4 silencer

Naoe, Y, Setoguchi, R, Akiyama, K, Muroi, S, Kuroda, M, Hatam, F, Littman, DR, Taniuchi, I

J Exp Med 2007
24249732 Genome-wide regulatory analysis reveals that T-bet controls Th17 lineage differentiation through direct suppression of IRF4

Gökmen, MR, Dong, R, Kanhere, A, Powell, N, Perucha, E, Jackson, I, Howard, JK, Hernandez-Fuentes, M, Jenner, RG, Lord, GM

J Immunol 2013
Participants
Input
Output
Orthologous Events
TBX21 and RUNX3 bind the IL4 gene (Homo sapiens)
Authored
May, B  (2025-04-18)
Reviewed
Barbutti, I  (2025-08-04)
Lord, GM  (2025-08-05)
Created
May, B  (2025-04-20)
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