Btrc:Cul1:Skp1:Rbx1 ubiquitinylates phosphorylated Per1,2,3

Stable Identifier
R-MMU-9932505
Type
Reaction [omitted]
Species
Mus musculus
Compartment
cytosol
ReviewStatus
5/5
General
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Btrc:Cul1:Skp1:Rbx1 ubiquitinylates phosphorylated Per1,2,3
The SCF ubiquitin E3 ligase complex Btrc:Cul1:Skp1:Rbx1 binds phosphorylated mouse Per1 (Shirogane et al.2005) and, by inference other Per proteins, and catalyzes the polymerization of ubiquitin from ubiquitin:E2 complexes onto an unidentified lysine residue of Per1 (Shirogane et al. 2005) and Per2 (inferred from Btrc-dependent decay of Per2 in mouse cells in Eide et al. 2005, Reischl et al. 2007, Ohsaki et al. 2008).
Literature References
PubMed ID Title Journal Year
15917222 SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein

Shirogane, T, Jin, J, Ang, XL, Harper, JW

J Biol Chem 2005
Participants
Input
Output
Orthologous Events
BTRC:CUL1:SKP1:RBX1 (SCF-beta-TrCP1) ubiquitinylates phosphorylated PER1,2,3 (Homo sapiens)
Authored
May, B  (2024-12-20)
Reviewed
Sancar, A  (2025-02-14)
Albrecht, U  (2025-02-18)
Created
May, B  (2024-12-20)
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