Rora,c and coactivators bind the Clock gene

Stable Identifier
R-MMU-9932093
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
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Rora,c and coactivators bind the Clock gene
Either Rora or Rorc bind a single ROR response element (RRE, RORE) in the promoter of the Clock gene (Takeda et al. 2012). Upon binding RREs, Rora is coactivated by Ep300 and Ppargc1a (Pgc-1alpha) to enhance transcription (Lau et al. 2004). The Bmal1:Clock heterodimer directly activates transcription of Rora and Rorc, resulting in a circadian loop of expression.
Literature References
PubMed ID Title Journal Year
15199055 RORalpha regulates the expression of genes involved in lipid homeostasis in skeletal muscle cells: caveolin-3 and CPT-1 are direct targets of ROR

Lau, P, Nixon, SJ, Parton, RG, Muscat, GE

J Biol Chem 2004
22753030 RORĪ³ directly regulates the circadian expression of clock genes and downstream targets in vivo

Takeda, Y, Jothi, R, Birault, V, Jetten, AM

Nucleic Acids Res 2012
Participants
Input
Output
Orthologous Events
RORA,C and coactivators bind the CLOCK gene (Homo sapiens)
Authored
May, B  (2024-12-15)
Reviewed
Sancar, A  (2025-02-14)
Albrecht, U  (2025-02-18)
Created
May, B  (2024-12-17)
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