Rora,c, Ep300, and Ppargc1a bind the Nr1d1 gene

Stable Identifier
R-MMU-9931520
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Rora,c, Ep300, and Ppargc1a bind the Nr1d1 gene
Rora or Rorc bind two ROR responsive elements (RREs, ROREs) in the promoter of the Nr1d1 (Rev-erba) gene (Takeda et al. 2012) and recruit the coactivators Pgc-1alpha (Ppargc1a) and p300 (Ep300, a histone acetyltransferase) (Lau et al. 2004).
Literature References
PubMed ID Title Journal Year
15199055 RORalpha regulates the expression of genes involved in lipid homeostasis in skeletal muscle cells: caveolin-3 and CPT-1 are direct targets of ROR

Lau, P, Nixon, SJ, Parton, RG, Muscat, GE

J Biol Chem 2004
22753030 RORĪ³ directly regulates the circadian expression of clock genes and downstream targets in vivo

Takeda, Y, Jothi, R, Birault, V, Jetten, AM

Nucleic Acids Res 2012
Participants
Input
Output
Orthologous Events
RORA,C and coactivators bind the NR1D1 (REV-ERBA) gene (Homo sapiens)
Authored
May, B  (2024-12-12)
Reviewed
Sancar, A  (2025-02-14)
Albrecht, U  (2025-02-18)
Created
May, B  (2024-12-12)
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