p-S97-Bmal1:p-T451,T461-Clock and coactivators bind the Rorc gene

Stable Identifier
R-MMU-9926663
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
p-S97-Bmal1:p-T451,T461-Clock and coactivators bind the Rorc gene
A phosphorylated Bmal1:Clock heterodimer binds a site near the Rorc gene (Koike et al. 2012, Rey et al. 2011) and recruits the histone acetyltransferase Crebbp and the histone methyltransferase Kmt2a (Koike et al. 2012).
Literature References
PubMed ID Title Journal Year
21364973 Genome-wide and phase-specific DNA-binding rhythms of BMAL1 control circadian output functions in mouse liver

Rey, G, Cesbron, F, Rougemont, J, Reinke, H, Brunner, M, Naef, F

PLoS Biol. 2011
22936566 Transcriptional architecture and chromatin landscape of the core circadian clock in mammals

Koike, N, Yoo, SH, Huang, HC, Kumar, V, Lee, C, Kim, TK, Takahashi, JS

Science 2012
Participants
Input
Output
Orthologous Events
p-S90-BMAL1:p-T451,T461-CLOCK and coactivators bind the RORC gene (Homo sapiens)
Authored
May, B  (2024-11-01)
Reviewed
Sancar, A  (2025-02-14)
Albrecht, U  (2025-02-18)
Created
May, B  (2024-11-01)
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