p-S97-Bmal1:p-T451,T461-Clock,p-Npas2 and coactivators bind the Cry1 gene

Stable Identifier
R-MMU-9926600
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
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p-S97-Bmal1:p-T451,T461-Clock,p-Npas2 and coactivators bind the Cry1 gene
After entering the nucleus from the cytosol, p-S97-Bmal1:p-T451,T461-Clock heterodimers bind two E-boxes in the promoter of the Cry1 gene (Etchegaray et al. 2003, Mongrain et al. 2011, Rey et al. 2011, Koike et al. 2012, Chiou et al. 2016, Zhao et al. 2024). Kmt2a (Mll1) associates with Clock and is found at E-box promoter elements (Katada and Sassone-Corsi 2010). Kmt2a is a component of Mll1 histone acetyltransferase complexes, however, the association of other components of the Mll1 complex with Clock has not been demonstrated. The histone acetyltransferase Crebbp (Cbp) interacts with Bmal1 (Garg et al. 2019), however, the presence of Crebbp or Ep300 at the Cry1 promoter was not detected (Koike et al. 2012). Cry1 is a repressor of transcription activation by the p-S97-Bmal1:p-T451,T461-Clock heterodimer and thereby initiates the negative phase of the circadian cycle. Npas2 acts redundantly with Clock to form heterodimers with Bmal1 and regulate Cry1 expression (Reick et al. 2001).
Literature References
PubMed ID Title Journal Year
11441147 NPAS2: an analog of clock operative in the mammalian forebrain

Reick, M, Garcia, JA, Dudley, C, McKnight, SL

Science 2001
21113167 The histone methyltransferase MLL1 permits the oscillation of circadian gene expression

Katada, S, Sassone-Corsi, P

Nat Struct Mol Biol 2010
38183795 Identification of BMAL1-Regulated circadian genes in mouse liver and their potential association with hepatocellular carcinoma: Gys2 and Upp2 as promising candidates

Zhao, H, Han, G, Jiang, Z, Gao, D, Zhang, H, Yang, L, Ma, T, Gao, L, Wang, A, Chao, HW, Li, Q, Jin, Y, Chen, H

Biochem Biophys Res Commun 2024
22039518 Sleep loss reduces the DNA-binding of BMAL1, CLOCK, and NPAS2 to specific clock genes in the mouse cerebral cortex

Mongrain, V, La Spada, F, Curie, T, Franken, P

PLoS One 2011
21364973 Genome-wide and phase-specific DNA-binding rhythms of BMAL1 control circadian output functions in mouse liver

Rey, G, Cesbron, F, Rougemont, J, Reinke, H, Brunner, M, Naef, F

PLoS Biol. 2011
27688755 Mammalian Period represses and de-represses transcription by displacing CLOCK-BMAL1 from promoters in a Cryptochrome-dependent manner

Chiou, YY, Yang, Y, Rashid, N, Ye, R, Selby, CP, Sancar, A

Proc. Natl. Acad. Sci. U.S.A. 2016
22936566 Transcriptional architecture and chromatin landscape of the core circadian clock in mammals

Koike, N, Yoo, SH, Huang, HC, Kumar, V, Lee, C, Kim, TK, Takahashi, JS

Science 2012
12483227 Rhythmic histone acetylation underlies transcription in the mammalian circadian clock

Etchegaray, JP, Lee, C, Wade, PA, Reppert, SM

Nature 2003
Participants
Input
Output
Orthologous Events
p-S90-BMAL1:p-T451,T461-CLOCK,p-NPAS2 and coactivators bind the CRY1 gene (Homo sapiens)
Authored
May, B  (2024-11-01)
Reviewed
Sancar, A  (2025-02-14)
Albrecht, U  (2025-02-18)
Created
May, B  (2024-11-01)
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