Reactome | Phosphorylated Bmal1:Clock and coactivators positively regulate expression of Cry1

Phosphorylated Bmal1:Clock and coactivators positively regulate expression of Cry1

Stable Identifier

R-MMU-9926584

Type

Reaction [omitted]

Species

Mus musculus

Compartment

nucleoplasm, cytosol

ReviewStatus

5/5

General

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Phosphorylated Bmal1:Clock and coactivators positively regulate expression of Cry1

Phosphorylated Bmal1:Clock bound to an E-box in the Cry1 promoter recruits histone acetyltransferase Crebbp and the histone methyltransferase Kmt2a and enhance transcription of Cry1 (Etchegaray et al. 2003, Kondratov et al. 2006, Liu et al. 2007). Cry1 expressed in a circadian rhythm (Miyamoto and Sancar 1999, Yamamoto et al. 2004) in all tissues tested (Kobayashi et al. 1998). Npas2 acts redundantly with Clock to regulate Cry1 expression (Reick et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
11441147	NPAS2: an analog of clock operative in the mammalian forebrain Reick, M, Garcia, JA, Dudley, C, McKnight, SL	Science	2001
17994338	Chronobiological analysis of circadian patterns in transcription of seven key clock genes in six peripheral tissues in mice Liu, S, Cai, Y, Sothern, RB, Guan, Y, Chan, P	Chronobiol Int	2007
9801304	Characterization of photolyase/blue-light receptor homologs in mouse and human cells Kobayashi, K, Kanno, S, Smit, B, van der Horst, GT, Takao, M, Yasui, A	Nucleic Acids Res	1998
10521578	Circadian regulation of cryptochrome genes in the mouse Miyamoto, Y, Sancar, A	Brain Res Mol Brain Res	1999
16507766	Dual role of the CLOCK/BMAL1 circadian complex in transcriptional regulation Kondratov, RV, Shamanna, RK, Kondratova, AA, Gorbacheva, VY, Antoch, MP	FASEB J	2006
15473909	Transcriptional oscillation of canonical clock genes in mouse peripheral tissues Yamamoto, T, Nakahata, Y, Soma, H, Akashi, M, Mamine, T, Takumi, T	BMC Mol Biol	2004
12483227	Rhythmic histone acetylation underlies transcription in the mammalian circadian clock Etchegaray, JP, Lee, C, Wade, PA, Reppert, SM	Nature	2003