Plin2 gene expression is positively regulated by Pparg:Rxra and Mll4,(Mll3) complex

Stable Identifier
R-MMU-9907270
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm, lipid droplet
ReviewStatus
5/5
General
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PNG
Low
Medium
High
 | PPTX  | SBGN
Plin2 gene expression is positively regulated by Pparg:Rxra and Mll4,(Mll3) complex
Treatment of mouse white preadipocyte cell line 3T3-L1 with PPARG agonists results in increased Plin2 mRNA levels (Bhalla et al. 2011). Expression of the Plin2 gene is severely reduced in differentiating mouse brown preadipocytes expressing histone H3.3 K4M mutant or Kmt2c (Mll3) and Kmt2d (Mll4) with deleted SET domains (Jang et al. 2019: RNA-seq, supplementary information).

In a mouse model of hepatic steatosis, expression of the Plin2 gene is directly stimulated by Pparg2 and the Mll4 complex but negatively regulated by imatinib, an Abl1 kinase inhibitor that disrupts Abl1-mediated association between Pparg2 and the Mll4 complex (Kim et al. 2016).
Literature References
PubMed ID Title Journal Year
27806304 Critical Roles of the Histone Methyltransferase MLL4/KMT2D in Murine Hepatic Steatosis Directed by ABL1 and PPARγ2

Kim, DH, Kim, J, Kwon, JS, Sandhu, J, Tontonoz, P, Lee, SK, Lee, S, Lee, JW

Cell Rep 2016
30335158 H3.3K4M destabilizes enhancer H3K4 methyltransferases MLL3/MLL4 and impairs adipose tissue development

Jang, Y, Broun, A, Wang, C, Park, YK, Zhuang, L, Lee, JE, Froimchuk, E, Liu, C, Ge, K

Nucleic Acids Res 2019
21979952 N-Acetylfarnesylcysteine is a novel class of peroxisome proliferator-activated receptor γ ligand with partial and full agonist activity in vitro and in vivo

Bhalla, K, Hwang, BJ, Choi, JH, Dewi, R, Ou, L, Mclenithan, J, Twaddel, W, Pozharski, E, Stock, J, Girnun, GD

J Biol Chem 2011
Participants
Input
Output
This event is regulated
Positively by
Regulator
Activated Pparg:Rxra:Plin2 gene:H3K4me1-Nucleosomes:Mll4,(Mll3)-ASCOM [nucleoplasm] (Mus musculus)
Active Unit
Mll4-ASCOM,(Mll3-ASCOM) [nucleoplasm]
Ncoas (Pparg,Rxra) [nucleoplasm]
PPARG natural ligands [nucleoplasm]
Pparg:Rxra [nucleoplasm]
RXRA natural ligands [nucleoplasm]
Orthologous Events
PLIN2 gene expression is stimulated by PPARG:RXRA:MLL4,(MLL3)-ASCOM complex (Homo sapiens)
Authored
Orlic-Milacic, M  (2024-04-05)
Reviewed
Aberin, MAE  (2025-10-31)
Wang, SP  (2025-10-31)
Created
Orlic-Milacic, M  (2024-04-05)
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