Pex11a gene expression is stimulated by Pparg:Rxra and Mll4,(Mll3) complex

Stable Identifier
R-MMU-9907261
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm, peroxisomal membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Pex11a gene expression is stimulated by Pparg:Rxra and Mll4,(Mll3) complex
Mouse Pex11a gene in clustered together with the Plin1 gene on chromosome 7. A PPAR response element (PPRE) is found in between the Pex11a gene and the downstream Plin1 gene, at ~8 kb downstream of Pex11a transcription start site (TSS), and ~2 kb upstream of the Plin1 TSS. The Pparg:Rxra heterodimer specifically binds this PPARE to stimulate transcription of both Pex11a and Plin1 (Shimizu et al. 2004, Shimizu et al. 2006). The arrangement of the PEX11A and PLIN1 genes and their shared regulatory elements are conserved in rats and humans (Shimizu et al. 2006). Expression of the Pex11a gene is severely reduced in differentiating mouse brown preadipocytes expressing histone H3.3 K4M mutant or Kmt2c (Mll3) and Kmt2d (Mll4) with deleted SET domains (Jang et al. 2019: RNA-seq, supplementary information).
Literature References
PubMed ID Title Journal Year
30335158 H3.3K4M destabilizes enhancer H3K4 methyltransferases MLL3/MLL4 and impairs adipose tissue development

Jang, Y, Broun, A, Wang, C, Park, YK, Zhuang, L, Lee, JE, Froimchuk, E, Liu, C, Ge, K

Nucleic Acids Res 2019
16567422 Peroxisome proliferator-activated receptor subtypes differentially cooperate with other transcription factors in selective transactivation of the perilipin/PEX11 alpha gene pair

Shimizu, M, Akter, MH, Emi, Y, Sato, R, Yamaguchi, T, Hirose, F, Osumi, T

J Biochem 2006
14729975 Tissue-selective, bidirectional regulation of PEX11 alpha and perilipin genes through a common peroxisome proliferator response element

Shimizu, M, Takeshita, A, Tsukamoto, T, Gonzalez, FJ, Osumi, T

Mol Cell Biol 2004
Participants
Input
Output
This event is regulated
Positively by
Regulator
Activated Pparg:Rxra:Pex11a gene:H3K4me1-Nucleosomes:Mll4,(Mll3)-ASCOM [nucleoplasm] (Mus musculus)
Active Unit
Mll4-ASCOM,(Mll3-ASCOM) [nucleoplasm]
Ncoas (Pparg,Rxra) [nucleoplasm]
PPARG natural ligands [nucleoplasm]
Pparg:Rxra [nucleoplasm]
RXRA natural ligands [nucleoplasm]
Orthologous Events
PEX11A gene expression is stimulated by PPARG:RXRA:MLL4,(MLL3)-ASCOM complex (Homo sapiens)
Authored
Orlic-Milacic, M  (2024-04-05)
Reviewed
Aberin, MAE  (2025-10-31)
Wang, SP  (2025-10-31)
Created
Orlic-Milacic, M  (2024-04-05)
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