Cidec gene expression is stimulated by Pparg:Rxra and Mll4,(Mll3) complex

Stable Identifier
R-MMU-9907178
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Cidec gene expression is stimulated by Pparg:Rxra and Mll4,(Mll3) complex
After the differentiation of mouse adipocytes, the expression pattern of Cidec is similar to that of Pparg2 (Kim et al. 2008). The level of Cidec mRNA in mouse adipocytes increases in the presence of PPARG agonists (Kim et al. 2008). By reporter assay, Pparg2 activates transcription from the mouse Cidec gene promoter (Kim et al. 2008). Growth hormone-mediated downregulation of Pparg activity in mouse white preadipocyte line 3T3-L1 leads to downregulation of Cidec expression (Sharma et al. 2018). Expression of the Cidec gene is severely reduced in differentiating mouse brown preadipocytes expressing histone H3.3 K4M mutant or Kmt2c (Mll3) and Kmt2d (Mll4) with deleted SET domains (Jang et al. 2019: RNA-seq, supplementary information). RNA Pol II occupancy at the mouse Cidec gene promoter is increased in response to PPARG agonists (Nielsen et al. 2008).

In a mouse model of hepatic steatosis, expression of the Cidec gene is directly stimulated by Pparg2 and the Mll4 complex, but negatively regulated by imatinib, an Abl1 kinase inhibitor that disrupts Abl1-mediated association between Pparg2 and the Mll4 complex (Kim et al. 2016).
Literature References
PubMed ID Title Journal Year
18981474 Genome-wide profiling of PPARgamma:RXR and RNA polymerase II occupancy reveals temporal activation of distinct metabolic pathways and changes in RXR dimer composition during adipogenesis

Nielsen, R, Pedersen, TA, Hagenbeek, D, Moulos, P, Siersbaek, R, Megens, E, Denissov, S, Børgesen, M, Francoijs, KJ, Mandrup, S, Stunnenberg, HG

Genes Dev 2008
27806304 Critical Roles of the Histone Methyltransferase MLL4/KMT2D in Murine Hepatic Steatosis Directed by ABL1 and PPARγ2

Kim, DH, Kim, J, Kwon, JS, Sandhu, J, Tontonoz, P, Lee, SK, Lee, S, Lee, JW

Cell Rep 2016
30335158 H3.3K4M destabilizes enhancer H3K4 methyltransferases MLL3/MLL4 and impairs adipose tissue development

Jang, Y, Broun, A, Wang, C, Park, YK, Zhuang, L, Lee, JE, Froimchuk, E, Liu, C, Ge, K

Nucleic Acids Res 2019
30400015 Growth hormone controls lipolysis by regulation of FSP27 expression

Sharma, R, Luong, Q, Sharma, VM, Harberson, M, Harper, B, Colborn, A, Berryman, DE, Jessen, N, Jørgensen, JOL, Kopchick, JJ, Puri, V, Lee, KY

J Endocrinol 2018
18845124 Transcriptional activation of Cidec by PPARgamma2 in adipocyte

Kim, YJ, Cho, SY, Yun, CH, Moon, YS, Lee, TR, Kim, SH

Biochem Biophys Res Commun 2008
Participants
Input
Output
This event is regulated
Positively by
Regulator
Activated Pparg:Rxra:Cidec gene:H3K4me1-Nucleosomes:Mll4,(Mll3)-ASCOM [nucleoplasm] (Mus musculus)
Active Unit
Mll4-ASCOM,(Mll3-ASCOM) [nucleoplasm]
Ncoas (Pparg,Rxra) [nucleoplasm]
PPARG natural ligands [nucleoplasm]
Pparg:Rxra [nucleoplasm]
RXRA natural ligands [nucleoplasm]
Orthologous Events
CIDEC gene expression is stimulated by PPARG:RXRA:MLL4,(MLL3)-ASCOM complex (Homo sapiens)
Authored
Orlic-Milacic, M  (2024-04-04)
Reviewed
Aberin, MAE  (2025-10-31)
Wang, SP  (2025-10-31)
Created
Orlic-Milacic, M  (2024-04-04)
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