p-T308,S473-Akt1 phosphorylates Itga5 (Integrin alpha5) in Itga5:Itgb1 (Integrin alpha5:Integrin beta1)

Stable Identifier
R-MMU-9857664
Type
Reaction [transition]
Species
Mus musculus
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
p-T308,S473-Akt1 phosphorylates Itga5 (Integrin alpha5) in Itga5:Itgb1 (Integrin alpha5:Integrin beta1)
Akt1 phosphorylated on threonine-308 and serine-475 phosphorylates integrin alpha5 (Itga5) on an unknown residue (Batra et al. 2014). Itga5 is located in a complex with integrin beta1 (Itgb1) in the plasma membrane of osteocytes (Batra et al. 2012).
Literature References
PubMed ID Title Journal Year
24563481 Direct regulation of osteocytic connexin 43 hemichannels through AKT kinase activated by mechanical stimulation

Batra, N, Riquelme, MA, Burra, S, Kar, R, Gu, S, Jiang, JX

J Biol Chem 2014
Participants
Input
Output
Catalyst Activity

protein serine/threonine kinase activity of p-T308,S473-Akt1 [cytosol]

Physical Entity
p-T308,S473-Akt1 [cytosol] (Mus musculus)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
p-T308,S473-AKT1 phosphorylates ITGA5 (Integrin alpha5) in ITGA5:ITGB1 (Integrin alpha5:Integrin beta1) (Homo sapiens)
Authored
May, B  (2024-01-05)
Reviewed
Farach-Carson, MC  (2024-10-27)
Wu, D  (2024-10-27)
Created
May, B  (2024-01-08)
Cite Us!