Cox7a1 gene expression is positively regulated by Ebf2

Stable Identifier
R-MMU-9844821
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm, mitochondrial inner membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Cox7a1 gene expression is positively regulated by Ebf2
In mouse brown and beige adipocyte lineages Cox7a1 gene expression is positively regulated by the transcription factor Ebf2 (Rajakumari et al. 2013; Wang et al. 2014; Stine et al. 2016). Loss of Ebf2 leads to a significant reduction in the level of active chromatin mark H3K27ac and RNA Pol II localization at the Cox7a1 gene (Shapira et al. 2017). The level of Blnc1 lncRNA which acts as a cofactor for Ebf2 positively correlates with Cox7a1 mRNA level (Zhao et al. 2014).
Literature References
PubMed ID Title Journal Year
25002143 A long noncoding RNA transcriptional regulatory circuit drives thermogenic adipocyte differentiation

Zhao, XY, Li, S, Wang, GX, Yu, Q, Lin, JD

Mol Cell 2014
28428261 EBF2 transcriptionally regulates brown adipogenesis via the histone reader DPF3 and the BAF chromatin remodeling complex

Shapira, SN, Lim, HW, Rajakumari, S, Sakers, AP, Ishibashi, J, Harms, MJ, Won, KJ, Seale, P

Genes Dev 2017
25197048 Ebf2 is a selective marker of brown and beige adipogenic precursor cells

Wang, W, Kissig, M, Rajakumari, S, Huang, L, Lim, HW, Won, KJ, Seale, P

Proc Natl Acad Sci U S A 2014
23499423 EBF2 determines and maintains brown adipocyte identity

Rajakumari, S, Wu, J, Ishibashi, J, Lim, HW, Giang, AH, Won, KJ, Reed, RR, Seale, P

Cell Metab 2013
26844207 EBF2 promotes the recruitment of beige adipocytes in white adipose tissue

Stine, RR, Shapira, SN, Lim, HW, Ishibashi, J, Harms, M, Won, KJ, Seale, P

Mol Metab 2016
Participants
Input
Output
This event is regulated
Positively by
Regulator
Ebf2, Ebf2:Blnc1 lncRNA:Hnrnpu [nucleoplasm] (Mus musculus)
Active Unit
Ebf2, Ebf2:Blnc1 lncRNA:Hnrnpu [nucleoplasm]
Orthologous Events
COX7A1 gene expression is stimulated by EBF2 (Homo sapiens)
Authored
Orlic-Milacic, M  (2023-09-25)
Reviewed
Chun, TH  (2023-12-01)
Created
Orlic-Milacic, M  (2023-09-22)
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