Fabp4 gene transcription is stimulated by Pparg:Rxra and Mll4,(Mll3) complex

Stable Identifier
R-MMU-9843904
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
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PNG
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Medium
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Fabp4 gene transcription is stimulated by Pparg:Rxra and Mll4,(Mll3) complex
Transcription of the Fabp4 (aP2) gene in mouse cell line HIB-1B derived from a brown adipose tissue tumor of a transgenic mouse was found to be directly stimulated by binding of the Pparg:Rxra heterodimer to an adipocyte specific enhancer (Tontonoz et al. 1994). Expression of Fabp4 is significantly down-regulated in white adipose tissue (WAT) of Kmt2c (Mll3) delta/delta mice that express H3K4 methyltransferase inactive Mll3 mutant (Lee et al. 2008). Expression of Fabp4 is completely ablated in Ncoa6-null mouse embryonic fibroblasts (MEFs), which also fail to differentiate into adipocytes (Qi et al. 2003). In mouse brown preadipocytes expressing histone 3 mutant H3.3 K4M expression of Fabp4 is reduced (Jang et al. 2019).
Literature References
PubMed ID Title Journal Year
30335158 H3.3K4M destabilizes enhancer H3K4 methyltransferases MLL3/MLL4 and impairs adipose tissue development

Jang, Y, Broun, A, Wang, C, Park, YK, Zhuang, L, Lee, JE, Froimchuk, E, Liu, C, Ge, K

Nucleic Acids Res 2019
7838715 Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR alpha

Tontonoz, P, Graves, RA, Budavari, AI, Erdjument-Bromage, H, Lui, M, Hu, E, Tempst, P, Spiegelman, BM

Nucleic Acids Res 1994
12754253 Transcriptional coactivator PRIP, the peroxisome proliferator-activated receptor gamma (PPARgamma)-interacting protein, is required for PPARgamma-mediated adipogenesis

Qi, C, Surapureddi, S, Zhu, YJ, Yu, S, Kashireddy, P, Rao, MS, Reddy, JK

J Biol Chem 2003
19047629 Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis

Lee, J, Saha, PK, Yang, QH, Lee, S, Park, JY, Suh, Y, Lee, SK, Chan, L, Roeder, RG, Lee, JW

Proc Natl Acad Sci U S A 2008
Participants
Input
Output
This event is regulated
Positively by
Regulator
Activated Pparg:Rxra:Fabp4 gene:H3K4me1-Nucleosomes:Mll4,(Mll3)-ASCOM [nucleoplasm] (Mus musculus)
Active Unit
Mll4-ASCOM,(Mll3-ASCOM) [nucleoplasm]
Ncoas (Pparg,Rxra) [nucleoplasm]
PPARG natural ligands [nucleoplasm]
Pparg:Rxra [nucleoplasm]
RXRA natural ligands [nucleoplasm]
Orthologous Events
FABP4 gene expression is stimulated by PPARG:RXRA:MLL4,(MLL3)-ASCOM complex (Homo sapiens)
Authored
Orlic-Milacic, M  (2023-09-12)
Reviewed
Aberin, MAE  (2025-10-31)
Wang, SP  (2025-10-31)
Created
Orlic-Milacic, M  (2023-09-12)
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