Hnf1b binds the Wnt9b gene

Stable Identifier
R-MMU-9833367
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
3/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Hnf1b binds the Wnt9b gene
Hnf1b binds two conserved sites 7.8 kb upstream of the Wnt9b coding region and a conserved site in the first intron of the Wnt9b gene (Lokmane et al. 2010). Based on the expression pattern of Hnf1b, the binding is believed to occur in the ureteric bud during nephron development (Lokmane et al. 2010). Wnt9b secreted by the ureteric bud induces Wnt4 expression in the renal vesicle.
Literature References
PubMed ID Title Journal Year
20040500 vHNF1 functions in distinct regulatory circuits to control ureteric bud branching and early nephrogenesis

Garcia-Villalba, P, Lokmane, L, Heliot, C, Cereghini, S, Fabre, M

Development 2010
Participants
Input
Output
Orthologous Events
HNF1B binds the WNT9B gene (Homo sapiens)
Authored
May, B  (2023-04-20)
Created
May, B  (2023-04-21)
Cite Us!