Expression of Zic2 in anterior neural plate

Stable Identifier
R-MMU-9832947
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Expression of Zic2 in anterior neural plate
Zic2 is expressed in early gastrulation in mesoderm, ectodermal cells facing the amniotic cavity, and in the presumptive headfold region (Nagai et al. 1997, Inoue et al. 2007). Zic2 is then expressed in neuroectoderm and becomes restricted to dorsal axial structures (Nagai et al. 1997, Inoue et al. 2007). Within the neural plate, Zic2 is expressed more highly in the anterior region than in the posterior region (Iwafuchi-Doi et al. 2012). Pou3f1 (Oct6) binds the Zic2 gene and activates expression in mouse embryonic stem cells (Zhu et al. 2014). Zic2 regulates a number of genes during neurulation including Sox2, Otx2, Zeb2, and Pou3f1 (Iwafuchi-Doi et al. 2012).
Literature References
PubMed ID Title Journal Year
24929964 The transcription factor Pou3f1 promotes neural fate commitment via activation of neural lineage genes and inhibition of external signaling pathways

Zhu, Q, Song, L, Peng, G, Sun, N, Chen, J, Zhang, T, Sheng, N, Tang, W, Qian, C, Qiao, Y, Tang, K, Han, JD, Li, J, Jing, N

Elife 2014
9070329 The expression of the mouse Zic1, Zic2, and Zic3 gene suggests an essential role for Zic genes in body pattern formation

Nagai, T, Aruga, J, Takada, S, Günther, T, Spörle, R, Schughart, K, Mikoshiba, K

Dev Biol 1997
22992956 Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells

Iwafuchi-Doi, M, Matsuda, K, Murakami, K, Niwa, H, Tesar, PJ, Aruga, J, Matsuo, I, Kondoh, H

Development 2012
17490632 Zic2 and Zic3 synergistically control neurulation and segmentation of paraxial mesoderm in mouse embryo

Inoue, T, Ota, M, Mikoshiba, K, Aruga, J

Dev Biol 2007
Participants
Input
Output
This event is regulated
Positively by
Regulator
Pou3f1:Zic2 gene [nucleoplasm] (Mus musculus)
Active Unit
Pou3f1 [nucleoplasm]
Orthologous Events
Expression of ZIC2 in anterior neural plate (Homo sapiens)
Authored
May, B  (2023-04-10)
Reviewed
Kondoh, H  (2023-07-12)
Created
May, B  (2023-04-10)
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