Expression of Pou3f1 in anterior neural plate

Stable Identifier
R-MMU-9832830
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Expression of Pou3f1 in anterior neural plate
Pou3f1 (Oct6) is expressed in the anterior ectoderm of the gastrulating embryo and continues expression in the anterior neural plate and neural groove (Zwart et al. 1996, Iwafuchi-Doi et al. 2012, Kondoh et al. 2016). Pou3f1 is expressed at a significantly higher level in the anterior neural plate than in the posterior neural plate (Iwafuchi-Doi et al. 2012, Kondoh et al. 2016, reviewed in Tang et al. 2015). Pou3f1 directly regulates a large number of neural markers including Sox2, Znf521 (Zfp521), Pax6, Zeb2 (SIP1), Zic2, and Otx2 (Zhu et al. 2014). Nanog directly represses Pou3f1 thereby limiting the timing and extent of neural differentiation (Barral et al. 2019).
Literature References
PubMed ID Title Journal Year
22992956 Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells

Iwafuchi-Doi, M, Matsuda, K, Murakami, K, Niwa, H, Tesar, PJ, Aruga, J, Matsuo, I, Kondoh, H

Development 2012
27279156 Axial level-dependent molecular and cellular mechanisms underlying the genesis of the embryonic neural plate

Kondoh, H, Takada, S, Takemoto, T

Dev Growth Differ 2016
8652411 The restricted expression pattern of the POU factor Oct-6 during early development of the mouse nervous system

Zwart, R, Broos, L, Grosveld, G, Meijer, D

Mech Dev 1996
31791948 Nanog regulates Pou3f1 expression at the exit from pluripotency during gastrulation

Barral, A, Rollan, I, Sanchez-Iranzo, H, Jawaid, W, Badia-Careaga, C, Menchero, S, Gomez, MJ, Torroja, C, Sánchez-Cabo, F, Göttgens, B, Manzanares, M, Sainz de Aja, J

Biol Open 2019
Participants
Input
Output
This event is regulated
Negatively by
Regulator
Nanog:Pou3f1 gene [nucleoplasm] (Mus musculus)
Active Unit
Nanog [nucleoplasm]
Orthologous Events
Expression of POU3F1 in anterior neural plate (Homo sapiens)
Authored
May, B  (2023-04-09)
Reviewed
Kondoh, H  (2023-07-12)
Created
May, B  (2023-04-09)
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