Expression of Six1 in metanephric mesenchyme

Stable Identifier
R-MMU-9831048
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
3/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Expression of Six1 in metanephric mesenchyme
Sine oculis homolog 1 (Six1) is expressed in metanephric mesenchyme before, during, and after induction of the ureteric bud in the nephric duct (Xu et al. 2003). In mice lacking Six1 the ureteric bud fails to invade the metanephric mesenchyme and the mesenchyme apoptoses (Xu et al. 2003). Eya1 enhances expression of Six1 and expression of Six1 is reduced but not absent in mice lacking Eya1 (Xu et al. 1999).
Literature References
PubMed ID Title Journal Year
10471511 Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia

Xu, PX, Adams, J, Peters, H, Brown, MC, Heaney, S, Maas, R

Nat Genet 1999
12783782 Six1 is required for the early organogenesis of mammalian kidney

Xu, PX, Zheng, W, Huang, L, Maire, P, Laclef, C, Silvius, D

Development 2003
Participants
Input
Output
This event is regulated
Positively by
Regulator
Eya1 [nucleoplasm] (Mus musculus)
Orthologous Events
Expression of SIX1 in metanephric mesenchyme (Homo sapiens)
Authored
May, B  (2023-03-17)
Created
May, B  (2023-03-17)
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