Reactome | Expression of Six1 in metanephric mesenchyme

Expression of Six1 in metanephric mesenchyme

Stable Identifier

R-MMU-9831048

Type

Reaction [omitted]

Species

Mus musculus

Compartment

nucleoplasm

ReviewStatus

3/5

General

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Expression of Six1 in metanephric mesenchyme

Sine oculis homolog 1 (Six1) is expressed in metanephric mesenchyme before, during, and after induction of the ureteric bud in the nephric duct (Xu et al. 2003). In mice lacking Six1 the ureteric bud fails to invade the metanephric mesenchyme and the mesenchyme apoptoses (Xu et al. 2003). Eya1 enhances expression of Six1 and expression of Six1 is reduced but not absent in mice lacking Eya1 (Xu et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
10471511	Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia Maas, R, Adams, J, Brown, MC, Xu, PX, Peters, H, Heaney, S	Nat Genet	1999
12783782	Six1 is required for the early organogenesis of mammalian kidney Xu, PX, Silvius, D, Zheng, W, Huang, L, Laclef, C, Maire, P	Development	2003