Expression of Plac8 in the nephric duct

Stable Identifier
R-MMU-9830432
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
3/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Expression of Plac8 in the nephric duct
Pax2 binds about 70 kb upstream of the transcription start site of the Plac8 gene and activates expression in the developing nephric duct (Boualia et al. 2013). Expression of Plac8 is lost in mouse embryos homozygous null for Pax2 and heterozygous null for Pax8 (Boualia et al. 2013).
Literature References
PubMed ID Title Journal Year
23920117 A core transcriptional network composed of Pax2/8, Gata3 and Lim1 regulates key players of pro/mesonephros morphogenesis

Boualia, SK, Gaitan, Y, Tremblay, M, Sharma, R, Cardin, J, Kania, A, Bouchard, M

Dev Biol 2013
Participants
Input
Output
This event is regulated
Positively by
Regulator
Pax2:Plac8 gene [nucleoplasm] (Mus musculus)
Active Unit
Pax2 [nucleoplasm]
Orthologous Events
Expression of PLAC8 in the nephric duct (Homo sapiens)
Authored
May, B  (2023-03-10)
Created
May, B  (2023-03-12)
Cite Us!