Expression of Dll1 in presomitic mesoderm

Stable Identifier
R-MMU-9825286
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Expression of Dll1 in presomitic mesoderm
Expression of Dll1 is activated by Wnt signaling in paraxial mesoderm (Dunty et al. 2008) via Lef1, which binds multiple sites in the DLL1 promoter and recruits beta-catenin (Ctnnb1) (Galceran et al. 2004, Hofmann et al. 2004). Msgn1 binds two sites upstream of the Dll1 coding region and activates transcription during somite formation (Chalamalasetty et al. 2011, Chalamalasetty et al. 2014).
Literature References
PubMed ID Title Journal Year
15545628 WNT signaling, in synergy with T/TBX6, controls Notch signaling by regulating Dll1 expression in the presomitic mesoderm of mouse embryos

Hofmann, M, Schuster-Gossler, K, Watabe-Rudolph, M, Aulehla, A, Herrmann, BG, Gossler, A

Genes Dev 2004
21750544 The Wnt3a/β-catenin target gene Mesogenin1 controls the segmentation clock by activating a Notch signalling program

Chalamalasetty, RB, Dunty, WC, Biris, KK, Ajima, R, Iacovino, M, Beisaw, A, Feigenbaum, L, Chapman, DL, Yoon, JK, Kyba, M, Yamaguchi, TP

Nat Commun 2011
25371364 Mesogenin 1 is a master regulator of paraxial presomitic mesoderm differentiation

Chalamalasetty, RB, Garriock, RJ, Dunty, WC, Kennedy, MW, Jailwala, P, Si, H, Yamaguchi, TP

Development 2014
15545629 LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis

Galceran, J, Sustmann, C, Hsu, SC, Folberth, S, Grosschedl, R

Genes Dev 2004
18045842 Wnt3a/beta-catenin signaling controls posterior body development by coordinating mesoderm formation and segmentation

Dunty, WC, Biris, KK, Chalamalasetty, RB, Taketo, MM, Lewandoski, M, Yamaguchi, TP

Development 2008
Participants
Input
Output
This event is regulated
Positively by
Regulator
Msgn1:Lef1:Ctnnb1:Dll1 gene [nucleoplasm] (Mus musculus)
Orthologous Events
Expression of DLL1 in presomitic mesoderm (Homo sapiens)
Authored
Chalamalasetty, RB  (2022-11-09)
Yamaguchi, TP  (2022-11-09)
Reviewed
May, B  (2023-05-12)
Created
May, B  (2023-01-25)
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