Kdm5b demethylates histone H3 trimethyllysine-4 (H3K4me3)

Stable Identifier
R-MMU-9822448
Type
Reaction [transition]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
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Kdm5b demethylates histone H3 trimethyllysine-4 (H3K4me3)
Kdm5b (PLU-1) in a complex with an Fe2+ cofactor demethylates histone H3 trimethyllysine-4 (H3K4me3, lysine-5 of the preprotein) (Dahl et al. 2016, and inferred from human homologs). Kdm5b and Kdm5a participate in removing broad regions of H3K4me3 spanning genes in 2-cell stage mouse embryos (Dahl et al. 2016).
Literature References
PubMed ID Title Journal Year
27626377 Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition

Dahl, JA, Jung, I, Aanes, H, Greggains, GD, Manaf, A, Lerdrup, M, Li, G, Kuan, S, Li, B, Lee, AY, Preissl, S, Jermstad, I, Haugen, MH, Suganthan, R, Bjørås, M, Hansen, K, Dalen, KT, Fedorcsak, P, Ren, B, Klungland, A

Nature 2016
Participants
Input
Output
Catalyst Activity

histone H3K4 demethylase activity of Kdm5b:Fe2+ [nucleoplasm]

Physical Entity
Kdm5b:Fe2+ [nucleoplasm] (Mus musculus)
Activity
histone H3K4 demethylase activity (GO:0032453)
Orthologous Events
KDM5B demethylates histone H3 trimethyllysine-4 (H3K4me3) (Homo sapiens)
Authored
May, B  (2022-12-24)
Reviewed
Xie, W  (2023-08-08)
Created
May, B  (2022-12-24)
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