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Spata2 [cytosol]
Stable Identifier
R-MMU-9796351
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
SPATA2, Q8K004
Locations in the PathwayBrowser
Expand all
Signal Transduction (Mus musculus)
Death Receptor Signaling (Mus musculus)
TNF signaling (Mus musculus)
Regulation of TNFR1 signaling (Mus musculus)
CHUK, IKBKB phosphorylate RIPK1 at S25 (Mus musculus)
TNFα:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Mus musculus)
CYLD:SPATA2:LUBAC [cytosol] (Mus musculus)
Spata2 [cytosol] (Mus musculus)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Mus musculus)
CYLD:SPATA2:LUBAC [cytosol] (Mus musculus)
Spata2 [cytosol] (Mus musculus)
CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Mus musculus)
CYLD:SPATA2:LUBAC [cytosol] (Mus musculus)
Spata2 [cytosol] (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Mus musculus)
CYLD:SPATA2:LUBAC [cytosol] (Mus musculus)
Spata2 [cytosol] (Mus musculus)
CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Mus musculus)
CYLD:SPATA2:LUBAC [cytosol] (Mus musculus)
Spata2 [cytosol] (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Mus musculus)
CYLD:SPATA2:LUBAC [cytosol] (Mus musculus)
Spata2 [cytosol] (Mus musculus)
CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Mus musculus)
CYLD:SPATA2:LUBAC [cytosol] (Mus musculus)
Spata2 [cytosol] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Mus musculus)
CYLD:SPATA2:LUBAC [cytosol] (Mus musculus)
Spata2 [cytosol] (Mus musculus)
OPTN binds polyUb-RIPK1 within the TNFR1 complex (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Mus musculus)
CYLD:SPATA2:LUBAC [cytosol] (Mus musculus)
Spata2 [cytosol] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Mus musculus)
CYLD:SPATA2:LUBAC [cytosol] (Mus musculus)
Spata2 [cytosol] (Mus musculus)
OPTN recruits CYLD to the TNFR1 complex (Mus musculus)
CYLD:OPTN:polyUb-RIPK1:TNFR1 complex [plasma membrane] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Mus musculus)
CYLD:SPATA2:LUBAC [cytosol] (Mus musculus)
Spata2 [cytosol] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Mus musculus)
CYLD:SPATA2:LUBAC [cytosol] (Mus musculus)
Spata2 [cytosol] (Mus musculus)
SPATA2 links CYLD to LUBAC (Mus musculus)
CYLD:SPATA2:LUBAC [cytosol] (Mus musculus)
Spata2 [cytosol] (Mus musculus)
Spata2 [cytosol] (Mus musculus)
SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Mus musculus)
CYLD:SPATA2:LUBAC [cytosol] (Mus musculus)
Spata2 [cytosol] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Mus musculus)
CYLD:SPATA2:LUBAC [cytosol] (Mus musculus)
Spata2 [cytosol] (Mus musculus)
TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Mus musculus)
CYLD:SPATA2:LUBAC [cytosol] (Mus musculus)
Spata2 [cytosol] (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Mus musculus)
CYLD:SPATA2:LUBAC [cytosol] (Mus musculus)
Spata2 [cytosol] (Mus musculus)
TBK1, IKBKE phosphorylate RIPK1 at T189 (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Mus musculus)
CYLD:SPATA2:LUBAC [cytosol] (Mus musculus)
Spata2 [cytosol] (Mus musculus)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Mus musculus)
CYLD:SPATA2:LUBAC [cytosol] (Mus musculus)
Spata2 [cytosol] (Mus musculus)
TNFR1-induced NF-kappa-B signaling pathway (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Mus musculus)
CYLD:SPATA2:LUBAC [cytosol] (Mus musculus)
Spata2 [cytosol] (Mus musculus)
TNFR1-induced proapoptotic signaling (Mus musculus)
TRADD:TRAF2:RIP1 dissociates from TNF-α:TNFR1 (Mus musculus)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Mus musculus)
CYLD:SPATA2:LUBAC [cytosol] (Mus musculus)
Spata2 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:Q8K004
Gene Names
Spata2
Reference Genes
BioGPS Gene:263876 Spata2
ENSEMBL:ENSMUSG00000047030
KEGG:mmu:263876 Spata2
Monarch:263876 Spata2
NCBI Gene:263876 Spata2
UCSC:Q8K004 Spata2
Reference Transcript
RefSeq:NM_170756.3 Spata2
RefSeq:XM_017318650.3 Spata2
RefSeq:NM_001411394.1 Spata2
RefSeq:NM_001411395.1 Spata2
RefSeq:NM_001411396.1 Spata2
RefSeq:NM_001411397.1 Spata2
RefSeq:NM_001411398.1 Spata2
RefSeq:NM_001411393.1 Spata2
RefSeq:NM_001356523.2 Spata2
Other Identifiers
10489904
115171_at
1434107_at
1456776_at
17394707
263876
4485963
4525619
4604431
4605343
4768442
4780747
4809416
4850220
5078574
5102225
5121360
5129908
5130723
5168740
5419865
5484099
5486487
A_51_P110699
A_52_P514306
A_55_P2147141
A_55_P2152605
A_55_P2740456
GE137214
GO:0001650
GO:0005634
GO:0005654
GO:0005737
GO:0007283
GO:0010803
GO:0012501
GO:0022414
GO:0030159
GO:0044877
GO:0048856
GO:0050727
GO:0060090
GO:0060544
GO:0070266
GO:0070536
GO:0072520
GO:1990108
GO:1990381
ILMN_2444532
ILMN_2640415
ILMN_2692815
mMC022251
mMR026530
mMR030066
Participates
as an input of
SPATA2 links CYLD to LUBAC (Mus musculus)
as a component of
CYLD:SPATA2:LUBAC [cytosol] (Mus musculus)
Inferred From
SPATA2 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001398322.1
,
NP_001398327.1
,
NP_001398325.1
,
NP_001398326.1
,
NP_001398324.1
,
NP_001343452.1
,
XP_017174139.1
,
NP_001398323.1
,
NP_739562.1
ENSEMBL
ENSMUST00000057627
,
ENSMUSG00000047030
,
ENSMUST00000109211
,
ENSMUSP00000104834
,
ENSMUSP00000057095
PRO
Q8K004
MGI
2146885
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