Srf stimulates Npas4 gene transcription

Stable Identifier
R-MMU-9768820
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Srf stimulates Npas4 gene transcription
In mouse neurons, Srf (serum response factor) stimulates Npas4 gene transcription (Kuzniewska et al. 2016, Lösing et al. 2017, Förstner and Knöll 2019) by directly binding to evolutionarily conserved Srf binding sites in the promoter region of the Npas4 gene (Kuzniewska et al. 2016).
Literature References
PubMed ID Title Journal Year
25636686 Adult Deletion of SRF Increases Epileptogenesis and Decreases Activity-Induced Gene Expression

Kuzniewska, B, Nader, K, Dabrowski, M, Kaczmarek, L, Kalita, K

Mol Neurobiol 2016
Participants
Input
Output
This event is regulated
Positively by
Regulator
Srf:Npas4 gene [nucleoplasm] (Mus musculus)
Active Unit
Srf [nucleoplasm]
Orthologous Events
SRF stimulates NPAS4 gene transcription (Homo sapiens)
Authored
Orlic-Milacic, M  (2022-04-08)
Reviewed
Lin, Y  (2022-07-29)
Created
Orlic-Milacic, M  (2022-03-14)
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