Reactome | Asb10 [cytosol]

Asb10 [cytosol]

Stable Identifier

R-MMU-975417

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

ASB10, Q91ZT7

Locations in the PathwayBrowser

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Immune System (Mus musculus)

- Adaptive Immune System (Mus musculus)
  - Class I MHC mediated antigen processing & presentation (Mus musculus)
    - Antigen processing: Ubiquitination & Proteasome degradation (Mus musculus)
      - Interaction of E3 with substrate and E2-Ub complex (Mus musculus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Mus musculus)
        
        ASB family [cytosol] (Mus musculus)
        
        Asb10 [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Mus musculus)
        
        ASB family [cytosol] (Mus musculus)
        
        Asb10 [cytosol] (Mus musculus)
      - Polyubiquitination of substrate (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Mus musculus)
        
        ASB family [cytosol] (Mus musculus)
        
        Asb10 [cytosol] (Mus musculus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Mus musculus)
        
        ASB family [cytosol] (Mus musculus)
        
        Asb10 [cytosol] (Mus musculus)
        
        E3:Ub:substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Mus musculus)
        
        ASB family [cytosol] (Mus musculus)
        
        Asb10 [cytosol] (Mus musculus)
      - Release of E3 from polyubiquitinated substrate (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Mus musculus)
        
        ASB family [cytosol] (Mus musculus)
        
        Asb10 [cytosol] (Mus musculus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Mus musculus)
        
        ASB family [cytosol] (Mus musculus)
        
        Asb10 [cytosol] (Mus musculus)
      - Transfer of Ub from E2 to substrate and release of E2 (Mus musculus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Mus musculus)
        
        ASB family [cytosol] (Mus musculus)
        
        Asb10 [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Mus musculus)
        
        ASB family [cytosol] (Mus musculus)
        
        Asb10 [cytosol] (Mus musculus)
        
        E3:Ub:substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Mus musculus)
        
        ASB family [cytosol] (Mus musculus)
        
        Asb10 [cytosol] (Mus musculus)

Metabolism of proteins (Mus musculus)

- Post-translational protein modification (Mus musculus)
  - Neddylation (Mus musculus)
    - AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Mus musculus)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL5-box protein [cytosol] (Mus musculus)
        
        Asb10 [cytosol] (Mus musculus)
      - NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Mus musculus)
        
        CUL5-box protein [cytosol] (Mus musculus)
        
        Asb10 [cytosol] (Mus musculus)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Mus musculus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Mus musculus)
        
        CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL5-box protein [cytosol] (Mus musculus)
        
        Asb10 [cytosol] (Mus musculus)
      - CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL5-box protein [cytosol] (Mus musculus)
        
        Asb10 [cytosol] (Mus musculus)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Mus musculus)
        
        CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL5-box protein [cytosol] (Mus musculus)
        
        Asb10 [cytosol] (Mus musculus)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL5-box protein [cytosol] (Mus musculus)
        
        Asb10 [cytosol] (Mus musculus)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL5-box protein [cytosol] (Mus musculus)
        
        Asb10 [cytosol] (Mus musculus)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Mus musculus)
        
        CUL5-box protein [cytosol] (Mus musculus)
        
        Asb10 [cytosol] (Mus musculus)
    - NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Mus musculus)
      - CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL5-box protein [cytosol] (Mus musculus)
        
        Asb10 [cytosol] (Mus musculus)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL5-box protein [cytosol] (Mus musculus)
        
        Asb10 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q91ZT7

Gene Names

Asb10

Reference Genes

BioGPS Gene:117590 Asb10

ENSEMBL:ENSMUSG00000038204

KEGG:mmu:117590 Asb10

Monarch:117590 Asb10

NCBI Gene:117590 Asb10

UCSC:Q91ZT7 Asb10

Reference Transcript

Other Identifiers

10528622

117590

1421466_at

1441581_at

17446220

4465641

4497641

4517305

4548469

4587445

4777315

4801018

5029790

5135741

5459455

5543682

A_51_P406188

A_55_P2044710

GE126271

GO:0003674

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0008150

GO:0016567

GO:0035556

ILMN_2602682

ILMN_2919777

mMC005569

Participates

as a member of

Inferred From

ASB10 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001297405.1, NP_536692.1

ENSEMBL

ENSMUST00000048302, ENSMUSG00000038204, ENSMUSP00000041539

PRO

Q91ZT7

MGI

2152836

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