Reactome | Expression of Olfactory Receptor

Expression of Olfactory Receptor

Stable Identifier

R-MMU-9753126

Type

Reaction [omitted]

Species

Mus musculus

Compartment

nucleoplasm, endoplasmic reticulum membrane

ReviewStatus

5/5

General

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An olfactory receptor (OR) gene is transcribed to yield mRNA and the mRNA is translated to yield OR protein initially located in the endoplasmic reticulum membrane and then translocated through the Golgi to the plasma membrane (Saito et al. 2004, Zhang et al. 2016, Monahan et al. 2017, Monahan et al. 2019). Each mature olfactory sensory neuron expresses only one olfactory receptor (OR) (Hanchate et al. 2015, Saraiva et al. 2015). Lhx2, Ldb1, and Ebf1 bind intergenic olfactory enhancers and activate transcription (Zhang et al. 2016, Monahan et al. 2019). Deletion of Lhx2 causes loss of OR expression (Hirota and Mombaerts 2004, Kolterud et al. 2004, Hirota et al. 2007, Berghard et al. 2012, Zhang et al. 2016, Monahan et al. 2019). Heterochromatic silencing governed by Ehmt2 (Kmt1c, G9a) and Ehmt1 (Kmt1d, GLP) is required for singular receptor expression and produces a diversity of OR gene expression (Lyons et al. 2014). Olfactory enhancers interact interchromosomally to activate transcription of an OR gene (Markenscoff-Papadimitriou et al. 2014, Monahan et al. 2017, Monahan et al. 2019).

Literature References

PubMed ID	Title	Journal	Year
15550249	RTP family members induce functional expression of mammalian odorant receptors Saito, H, Kubota, M, Roberts, RW, Chi, Q, Matsunami, H	Cell	2004
15173589	The LIM-homeodomain protein Lhx2 is required for complete development of mouse olfactory sensory neurons Hirota, J, Mombaerts, P	Proc Natl Acad Sci U S A	2004
26541607	Single-cell transcriptomics reveals receptor transformations during olfactory neurogenesis Hanchate, NK, Kondoh, K, Lu, Z, Kuang, D, Ye, X, Qiu, X, Pachter, L, Trapnell, C, Buck, LB	Science	2015
28933695	Cooperative interactions enable singular olfactory receptor expression in mouse olfactory neurons Monahan, K, Schieren, I, Cheung, J, Mumbey-Wafula, A, Monuki, ES, Lomvardas, S	Elife	2017
15456728	The Lim homeobox gene Lhx2 is required for olfactory sensory neuron identity Kolterud, A, Alenius, M, Carlsson, L, Bohm, S	Development	2004
30626972	LHX2- and LDB1-mediated trans interactions regulate olfactory receptor choice Monahan, K, Horta, A, Lomvardas, S	Nature	2019
25417106	Enhancer interaction networks as a means for singular olfactory receptor expression Markenscoff-Papadimitriou, E, Allen, WE, Colquitt, BM, Goh, T, Murphy, KK, Monahan, K, Mosley, CP, Ahituv, N, Lomvardas, S	Cell	2014
22581782	Lhx2-dependent specification of olfactory sensory neurons is required for successful integration of olfactory, vomeronasal, and GnRH neurons Berghard, A, Hägglund, AC, Bohm, S, Carlsson, L	FASEB J	2012
27822500	Lhx2 Determines Odorant Receptor Expression Frequency in Mature Olfactory Sensory Neurons Zhang, G, Titlow, WB, Biecker, SM, Stromberg, AJ, McClintock, TS	eNeuro	2016
17350283	Differential impact of Lhx2 deficiency on expression of class I and class II odorant receptor genes in mouse Hirota, J, Omura, M, Mombaerts, P	Mol Cell Neurosci	2007
25437545	Heterochromatin-mediated gene silencing facilitates the diversification of olfactory neurons Lyons, DB, Magklara, A, Goh, T, Sampath, SC, Schaefer, A, Schotta, G, Lomvardas, S	Cell Rep	2014
26670777	Hierarchical deconstruction of mouse olfactory sensory neurons: from whole mucosa to single-cell RNA-seq Saraiva, LR, Ibarra-Soria, X, Khan, M, Omura, M, Scialdone, A, Mombaerts, P, Marioni, JC, Logan, DW	Sci Rep	2015