Rtp1s and Rtp2 bind underrepresented Olfactory Receptor

Stable Identifier
R-MMU-9753035
Type
Reaction [binding]
Species
Mus musculus
Compartment
endoplasmic reticulum membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Rtp1s and Rtp2 bind underrepresented Olfactory Receptor
The chaperone-like proteins RTP1S (the short isoform of RTP1) and RTP2 bind olfactory receptor (OR) proteins in the endoplasmic reticulum membrane (Saito et al. 2004, Sharma et al. 2017, Yu et al. 2017, Fukutani et al. 2019). In the absence of RTPs, most ORs are inefficiently translocated to the plasma membrane and accumulate in the Golgi and endoplasmic reticulum (Saito et al. 2004, Sharma et al. 2017). Some ORs are, however, translocated efficiently. Efficiently translocated ORs are called overrepresented ORs; inefficiently translocated ORs are called underrepresented ORs (Sharma et al. 2017). RTP2 inhibits translocation of some ORs (Yu et al. 2017). The mechanism by which RTP1S and RTP2 facilitate translocation of ORs to the plasma membrane is not yet known.
Literature References
PubMed ID Title Journal Year
15550249 RTP family members induce functional expression of mammalian odorant receptors

Saito, H, Kubota, M, Roberts, RW, Chi, Q, Matsunami, H

Cell 2004
28262096 Olfactory receptor accessory proteins play crucial roles in receptor function and gene choice

Sharma, R, Ishimaru, Y, Davison, I, Ikegami, K, Chien, MS, You, H, Chi, Q, Kubota, M, Yohda, M, Ehlers, M, Matsunami, H

Elife 2017
31395660 The N-terminal region of RTP1S plays important roles in dimer formation and odorant receptor-trafficking

Fukutani, Y, Tamaki, R, Inoue, R, Koshizawa, T, Sakashita, S, Ikegami, K, Ohsawa, I, Matsunami, H, Yohda, M

J Biol Chem 2019
28586385 Receptor-transporting protein (RTP) family members play divergent roles in the functional expression of odorant receptors

Yu, T, Su, X, Pan, Y, Zhuang, H

PLoS One 2017
Participants
Input
Output
Orthologous Events
RTP1S and RTP2 bind underrepresented Olfactory Receptors (uORs) (Homo sapiens)
Authored
May, B  (2021-09-06)
Reviewed
Raimondi, F  (2021-11-10)
Created
May, B  (2021-09-06)
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