Trpm5 transports Na+ from the extracellular region to the cytosol

Stable Identifier
R-MMU-9717433
Type
Reaction [transition]
Species
Mus musculus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Trpm5 transports Na+ from the extracellular region to the cytosol
Trpm5 is activated by calcium ions and passively transports monovalent cations across the plasma membrane, resulting in depolarization of the cell (Hofmann et al. 2003, Liu and Liman 2003, Talavera et al. 2005, Ullrich et al. 2005, Zhang et al. 2007, Uchida et al. 2021). In mice, Trpm4 and Trpm5 are involved in sodium signals in type II taste cells and are required for perception of sweet, bitter, and umami tastes (Dutta Banik et al. 2018, Yoshida et al. 2018). Trpm5 is approximately 28-fold more sensitive to calcium than Trpm4 is (Ullrich et al. 2005).
Literature References
PubMed ID Title Journal Year
12842017 TRPM5 is a voltage-modulated and Ca(2+)-activated monovalent selective cation channel

Chubanov, V, Hofmann, T, Gudermann, T, Montell, C

Curr Biol 2003
29113930 Bitter Taste Responses of Gustducin-positive Taste Cells in Mouse Fungiform and Circumvallate Papillae

Takai, S, Margolskee, RF, Shigemura, N, Yoshida, R, Ninomiya, Y, Sanematsu, K

Neuroscience 2018
33553759 Involvement of pore helix in voltage-dependent inactivation of TRPM5 channel

Okumura, H, Tominaga, M, Itoh, SG, Uchida, K, Yamazaki, J, Kita, T, Hatta, M

Heliyon 2021
14657398 Intracellular Ca2+ and the phospholipid PIP2 regulate the taste transduction ion channel TRPM5

Liman, ER, Liu, D

Proc Natl Acad Sci U S A 2003
16355226 Heat activation of TRPM5 underlies thermal sensitivity of sweet taste

Droogmans, G, Talavera, K, Margolskee, RF, Yasumatsu, K, Shigemura, N, Nilius, B, Voets, T, Ninomiya, Y

Nature 2005
15670874 Comparison of functional properties of the Ca2+-activated cation channels TRPM4 and TRPM5 from mice

Droogmans, G, Talavera, K, Vennekens, R, Nilius, B, Prenen, J, Voets, T, Ullrich, ND

Cell Calcium 2005
17522321 The transduction channel TRPM5 is gated by intracellular calcium in taste cells

Liman, E, Margolskee, R, Zhao, Z, Zhang, Z

J Neurosci 2007
Participants
Input
Output
Catalyst Activity

sodium channel activity of Trpm5 tetramer [plasma membrane]

Physical Entity
Trpm5 tetramer [plasma membrane] (Mus musculus)
Activity
sodium channel activity (GO:0005272)
This event is regulated
Positively by
Regulator
Ca2+ [cytosol]
Orthologous Events
TRPM5 transports Na+ from the extracellular region to the cytosol (Homo sapiens)
Authored
May, B  (2021-03-10)
Reviewed
Jiang, P  (2021-08-08)
Created
May, B  (2021-03-10)
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