Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
ADAM17(215-824) [plasma membrane]
Stable Identifier
R-MMU-9663048
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
plasma membrane
Synonyms
Q9Z0F8
Locations in the PathwayBrowser
Expand all
Signal Transduction (Mus musculus)
Death Receptor Signaling (Mus musculus)
TNF signaling (Mus musculus)
TNF-α is cleaved by ADAM17 (TACE) (Mus musculus)
ADAM17 [plasma membrane] (Mus musculus)
ADAM17(215-824) [plasma membrane] (Mus musculus)
p75 NTR receptor-mediated signalling (Mus musculus)
Regulated proteolysis of p75NTR (Mus musculus)
alpha-secretase cleaves the p75NTR extracellular domain (Mus musculus)
p-S,T-ADAM17(215-827):Zn2+ [plasma membrane] (Mus musculus)
ADAM17(215-827):Zn2+ [plasma membrane] (Mus musculus)
ADAM17(215-824) [plasma membrane] (Mus musculus)
External Reference Information
External Reference
UniProt:Q9Z0F8 Adam17
Gene Names
Adam17, Tace
Chain
signal peptide:1-17, propeptide:18-214, chain:215-827
Reference Genes
BioGPS Gene:11491 Adam17
KEGG:mmu:11491 Adam17
Monarch:11491 Adam17
NCBI Gene:11491 Adam17
UCSC:Q9Z0F8 Adam17
Reference Transcript
RefSeq:NM_009615.6 Adam17
RefSeq:NM_001277266.1 Adam17
RefSeq:NM_001291871.1 Adam17
Other Identifiers
10399605
11491
133576_at
1421857_at
1421858_at
1421859_at
17280207
4447971
4470262
4479802
4580878
4639302
4758762
4911155
4952415
5060001
5067725
5071912
5131700
5245258
5281111
5396665
5473075
5546164
A_52_P337050
A_52_P734595
A_55_P1999097
A_55_P2128188
A_55_P2612174
A_55_P2612184
GE37766
GO:0001666
GO:0002376
GO:0002467
GO:0002532
GO:0004175
GO:0004222
GO:0004252
GO:0005112
GO:0005138
GO:0005178
GO:0005515
GO:0005576
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0005911
GO:0005925
GO:0006508
GO:0006509
GO:0007155
GO:0007173
GO:0007219
GO:0007220
GO:0008233
GO:0008237
GO:0008284
GO:0009410
GO:0009967
GO:0009986
GO:0010820
GO:0010977
GO:0015629
GO:0016020
GO:0016324
GO:0016485
GO:0016787
GO:0017124
GO:0019955
GO:0023061
GO:0030154
GO:0030165
GO:0030183
GO:0030307
GO:0030335
GO:0030512
GO:0032496
GO:0032587
GO:0032722
GO:0032760
GO:0033025
GO:0033077
GO:0033627
GO:0035313
GO:0038134
GO:0038135
GO:0042987
GO:0043120
GO:0043491
GO:0043536
GO:0045121
GO:0045742
GO:0046872
GO:0048536
GO:0048679
GO:0048856
GO:0048870
GO:0050830
GO:0070573
GO:0071403
GO:0071679
GO:0098542
GO:0120163
GO:0140447
GO:0140448
GO:1900087
GO:1902945
GO:1903265
GO:1905564
GO:2001222
ILMN_1243942
ILMN_2594718
c76813_rc_s_at
mMR027797
Participates
as a component of
ADAM17(215-827):Zn2+ [plasma membrane] (Mus musculus)
ADAM17 [plasma membrane] (Mus musculus)
Other forms of this molecule
Adam17 [extracellular region]
Adam17 [plasma membrane]
ADAM 17 metalloprotease [plasma membrane]
Inferred From
ADAM17(215-824) [plasma membrane]
(Homo sapiens)
ADAM17 [plasma membrane]
(Homo sapiens)
Cross References
RefSeq
NP_001264195.1
,
NP_033745.4
,
NP_001278800.1
ENSEMBL
ENSMUST00000064536
,
ENSMUSG00000052593
,
ENSMUSP00000136407
,
ENSMUST00000145118
,
ENSMUSP00000067953
ZINC - Substances
ADA17_MOUSE
ZINC target
Q9Z0F8
PRO
Q9Z0F8
GlyGen
Q9Z0F8
MGI
1096335
ZINC - Predictions - Purchasable
ADA17_MOUSE
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q80WQ6 RHDF2
0.697
6
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text