ROS positively regulates misfolding of cilia proteins

Stable Identifier
R-MMU-9639715
Type
Reaction [transition]
Species
Mus musculus
Compartment
cilium
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
ROS positively regulates misfolding of cilia proteins
Accumulation of excessive reactive oxygen species (ROS) within cells results in oxidative stress. This stress can trigger proteins misfolding and make them dysfunctional. Cilia proteins are damaged when subjected to oxidative stress and may be targeted to the autophagy machinery. This results in the shortening of the cilium (Lam HC et al. 2013, Kim JI et al. 2013).
Literature References
PubMed ID Title Journal Year
23515720 Reduction of oxidative stress during recovery accelerates normalization of primary cilia length that is altered after ischemic injury in murine kidneys

Kim, JI, Kim, J, Jang, HS, Noh, MR, Lipschutz, JH, Park, KM

Am. J. Physiol. Renal Physiol. 2013
24200693 Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction

Lam, HC, Cloonan, SM, Bhashyam, AR, Haspel, JA, Singh, A, Sathirapongsasuti, JF, Cervo, M, Yao, H, Chung, AL, Mizumura, K, An, CH, Shan, B, Franks, JM, Haley, KJ, Owen, CA, Tesfaigzi, Y, Washko, GR, Quackenbush, J, Silverman, EK, Rahman, I, Kim, HP, Mahmood, A, Biswal, SS, Ryter, SW, Choi, AM

J. Clin. Invest. 2013
Participants
Input
Output
This event is regulated
Positively by
Regulator
ROS [cilium]
Orthologous Events
ROS positively regulates misfolding of cilia proteins (Homo sapiens)
Authored
Varusai, TM  (2019-03-18)
Reviewed
Metzakopian, E  (2019-05-24)
Created
Varusai, TM  (2019-03-19)
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