Impact binds Gcn1

Stable Identifier
R-MMU-9634671
Type
Reaction [binding]
Species
Mus musculus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Impact binds Gcn1
Impact, a mammalian homolog of yeast YIH1, competes with Eif2ak4 (Gcn2) for binding to Gcn1 (Pereira et al. 2005), which is required for activation of Gcn2 (Cambiaghi et al.2013) and may act by transferring unacylated tRNAs from the ribosome to Eif2ak4. Impact thereby inhibits phosphorylation of Eif2a by Eif2ak4 in response to amino acid deficiency (Pereira et al. 2005, Cambiaghi et al. 2013). Impact is preferentially expressed in neurons, associates with translating ribosomes, enhances translation initiation, and promotes neuritogenesis (Roffe et al. 2013).
Literature References
PubMed ID Title Journal Year
24333428 Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2

Cambiaghi, TD, Pereira, CM, Shanmugam, R, Bolech, M, Wek, RC, Sattlegger, E, Castilho, BA

Biochem. Biophys. Res. Commun. 2014
23447528 IMPACT is a developmentally regulated protein in neurons that opposes the eukaryotic initiation factor 2α kinase GCN2 in the modulation of neurite outgrowth

Roffé, M, Hajj, GN, Azevedo, HF, Alves, VS, Castilho, BA

J. Biol. Chem. 2013
15937339 IMPACT, a protein preferentially expressed in the mouse brain, binds GCN1 and inhibits GCN2 activation

Pereira, CM, Sattlegger, E, Jiang, HY, Longo, BM, Jaqueta, CB, Hinnebusch, AG, Wek, RC, Mello, LE, Castilho, BA

J. Biol. Chem. 2005
Participants
Input
Output
Orthologous Events
IMPACT binds GCN1 (Homo sapiens)
Authored
May, B  (2019-01-12)
Reviewed
Bruhat, A  (2019-09-15)
Staschke, KA  (2019-11-20)
Created
May, B  (2019-01-14)
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