Reactome | Rps27l [cytosol]

Rps27l [cytosol]

Stable Identifier

R-MMU-9633597

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

40S ribosomal protein S27-like, RS27L_MOUSE

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Mus musculus)

- Nonsense-Mediated Decay (NMD) (Mus musculus)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Mus musculus)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Mus musculus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27l [cytosol] (Mus musculus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27l [cytosol] (Mus musculus)
    - SMG6 hydrolyzes mRNA with premature termination codon (Mus musculus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27l [cytosol] (Mus musculus)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Mus musculus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27l [cytosol] (Mus musculus)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27l [cytosol] (Mus musculus)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Mus musculus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27l [cytosol] (Mus musculus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27l [cytosol] (Mus musculus)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Mus musculus)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Mus musculus)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27l [cytosol] (Mus musculus)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27l [cytosol] (Mus musculus)
- rRNA processing (Mus musculus)
  - rRNA processing in the nucleus and cytosol (Mus musculus)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Mus musculus)
      - 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27l [cytosol] (Mus musculus)

Metabolism of proteins (Mus musculus)

- Translation (Mus musculus)
  - Eukaryotic Translation Initiation (Mus musculus)
    - Cap-dependent Translation Initiation (Mus musculus)
      - Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Mus musculus)
        
        Translation initiation complex formation (Mus musculus)
        
        Formation of translation initiation complexes containing mRNA that does not circularize (Mus musculus)
        
        43S complex [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27l [cytosol] (Mus musculus)
        
        48S complex [cytosol] (Mus musculus)
        
        43S complex [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27l [cytosol] (Mus musculus)
        
        Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation (Mus musculus)
        
        43S complex [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27l [cytosol] (Mus musculus)
        
        43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Mus musculus)
        
        43S complex [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27l [cytosol] (Mus musculus)
      - Formation of a pool of free 40S subunits (Mus musculus)
        
        Release of 40S and 60S subunits from the 80S ribosome (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27l [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27l [cytosol] (Mus musculus)
        
        eIF3 and eIF1A bind to the 40S subunit (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27l [cytosol] (Mus musculus)
        
        40S:eIF3:eIF1A [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27l [cytosol] (Mus musculus)
      - Formation of the ternary complex, and subsequently, the 43S complex (Mus musculus)
        
        Formation of the 43S pre-initiation complex (Mus musculus)
        
        40S:eIF3:eIF1A [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27l [cytosol] (Mus musculus)
        
        43S complex [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27l [cytosol] (Mus musculus)
      - GTP hydrolysis and joining of the 60S ribosomal subunit (Mus musculus)
        
        The 60S subunit joins the translation initiation complex (Mus musculus)
        
        40S:Met-tRNAi:mRNA [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27l [cytosol] (Mus musculus)
        
        80S:Met-tRNAi:mRNA:eIF5B:GTP [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27l [cytosol] (Mus musculus)
        
        eIF2:GTP is hydrolyzed, eIFs are released (Mus musculus)
        
        40S:Met-tRNAi:mRNA [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27l [cytosol] (Mus musculus)
        
        48S complex [cytosol] (Mus musculus)
        
        43S complex [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27l [cytosol] (Mus musculus)
        
        eIF5B:GTP is hydrolyzed and released (Mus musculus)
        
        80S:Met-tRNAi:mRNA [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27l [cytosol] (Mus musculus)
        
        80S:Met-tRNAi:mRNA:eIF5B:GTP [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27l [cytosol] (Mus musculus)
      - Ribosomal scanning and start codon recognition (Mus musculus)
        
        Ribosomal scanning (Mus musculus)
        
        48S complex [cytosol] (Mus musculus)
        
        43S complex [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27l [cytosol] (Mus musculus)
        
        Start codon recognition (Mus musculus)
        
        48S complex [cytosol] (Mus musculus)
        
        43S complex [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27l [cytosol] (Mus musculus)
    - L13a-mediated translational silencing of Ceruloplasmin expression (Mus musculus)
      - Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Mus musculus)
        
        43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Mus musculus)
        
        43S complex [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27l [cytosol] (Mus musculus)
        
        phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Mus musculus)
        
        43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Mus musculus)
        
        43S complex [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27l [cytosol] (Mus musculus)
  - Ribosome-associated quality control (Mus musculus)
    - PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA (Mus musculus)
      - ABCE1:ATP binds PELO:HBS1L-1:GTP:80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide and HBS1L-1:GDP is released (Mus musculus)
        
        ABCE1:ATP:PELO:80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Mus musculus)
        
        80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27l [cytosol] (Mus musculus)
        
        PELO:HBS1L-1:GTP:80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide [cytosol] (Mus musculus)
        
        80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27l [cytosol] (Mus musculus)
      - ABCE1:PELO:80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide dissociates yielding ABCE1:40S ribosomal subunit, PELO, and 60S ribosomal subunit:peptidyl-tRNA with nascent peptide (Mus musculus)
        
        ABCE1:ADP:40S ribosomal subunit [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27l [cytosol] (Mus musculus)
        
        ABCE1:ATP:PELO:80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Mus musculus)
        
        80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27l [cytosol] (Mus musculus)
      - PELO:HBS1L-1:GTP binds 80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide (Mus musculus)
        
        80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27l [cytosol] (Mus musculus)
        
        PELO:HBS1L-1:GTP:80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide [cytosol] (Mus musculus)
        
        80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27l [cytosol] (Mus musculus)
    - ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA (Mus musculus)
      - RQT complex binds K63polyUb-80S ribosome:no-go mRNA:peptidyl-tRNA with nascent peptide (Mus musculus)
        
        K63polyUb-80S Ribosome:no-go mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Mus musculus)
        
        K63polyUb-80S ribosome [cytosol] (Mus musculus)
        
        K63polyUb-40S ribosomal subunit [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27l [cytosol] (Mus musculus)
        
        RQT complex:K63polyUb-80S Ribosome:no-go mRNA:peptidyl tRNA with nascent peptide [cytosol] (Mus musculus)
        
        K63polyUb-80S Ribosome:no-go mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Mus musculus)
        
        K63polyUb-80S ribosome [cytosol] (Mus musculus)
        
        K63polyUb-40S ribosomal subunit [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27l [cytosol] (Mus musculus)
      - ZNF598 K63 polyubiquitinates RPS10 (eS10) and RPS20 (uS10) of the 40S ribosomal subunit (Mus musculus)
        
        K63polyUb-80S Ribosome:no-go mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Mus musculus)
        
        K63polyUb-80S ribosome [cytosol] (Mus musculus)
        
        K63polyUb-40S ribosomal subunit [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27l [cytosol] (Mus musculus)
        
        ZNF598:Ub:UBE2D1,2,3:80S Ribosome:mRNA:peptidyl-tRNA with nascent peptide [cytosol] (Mus musculus)
        
        80S Ribosome:no-go mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27l [cytosol] (Mus musculus)
      - ZNF598 and Ub:UBE2D1,2,3 bind stalled 80S ribosome (Mus musculus)
        
        80S Ribosome:no-go mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27l [cytosol] (Mus musculus)
        
        ZNF598:Ub:UBE2D1,2,3:80S Ribosome:mRNA:peptidyl-tRNA with nascent peptide [cytosol] (Mus musculus)
        
        80S Ribosome:no-go mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27l [cytosol] (Mus musculus)
  - SRP-dependent cotranslational protein targeting to membrane (Mus musculus)
    - Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Mus musculus)
      - SRP:polypeptide+signal:ribosome [cytosol] (Mus musculus)
        
        ribosome:mRNA:polypeptide+signal [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27l [cytosol] (Mus musculus)
      - ribosome:mRNA:polypeptide+signal [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27l [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q6ZWY3 Rps27l

Gene Names

Rps27l

Chain

chain:1-84

Reference Genes

BioGPS Gene:67941 Rps27l

KEGG:mmu:67941 Rps27l

Monarch:67941 Rps27l

NCBI Gene:67941 Rps27l

UCSC:Q6ZWY3 Rps27l

Other Identifiers

10586604

1423254_x_at

1435429_x_at

1450925_a_at

17518799

4321711

4340884

4517301

4646535

4682520

4787370

4899282

5062643

5112711

5156172

5178697

5237379

5248388

5301040

5347239

67941

A_51_P246903

A_51_P246907

GE41254

GO:0000028

GO:0003723

GO:0003735

GO:0005198

GO:0005634

GO:0005829

GO:0005840

GO:0006412

GO:0008270

GO:0008494

GO:0022627

GO:0030330

GO:0031571

GO:0042771

GO:0045727

GO:0046872

GO:0065003

GO:1990904

ILMN_1251939

ILMN_2624280

mMC024691

Participates

as a member of

Rps27,Rps27l [cytosol] (Mus musculus)

as a candidate of

RPS27,RPS27L [cytosol] (Mus musculus)

Other forms of this molecule

Rps27l [nucleoplasm]

Inferred From

RPS27L [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_080743.1

ENSEMBL

ENSMUSG00000036781, ENSMUSP00000046016, ENSMUST00000040917

PRO

Q6ZWY3

MGI

1915191

PDB

7LS1, 7LS2

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