Reactome | Rpl22l1 [cytosol]

Rpl22l1 [cytosol]

Stable Identifier

R-MMU-9633587

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

60S ribosomal protein L22-like 1, RL22L_MOUSE

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Mus musculus)

- Nonsense-Mediated Decay (NMD) (Mus musculus)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Mus musculus)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Mus musculus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL22,RPL22L1 [cytosol] (Mus musculus)
        
        Rpl22l1 [cytosol] (Mus musculus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL22,RPL22L1 [cytosol] (Mus musculus)
        
        Rpl22l1 [cytosol] (Mus musculus)
    - SMG6 hydrolyzes mRNA with premature termination codon (Mus musculus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL22,RPL22L1 [cytosol] (Mus musculus)
        
        Rpl22l1 [cytosol] (Mus musculus)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Mus musculus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL22,RPL22L1 [cytosol] (Mus musculus)
        
        Rpl22l1 [cytosol] (Mus musculus)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL22,RPL22L1 [cytosol] (Mus musculus)
        
        Rpl22l1 [cytosol] (Mus musculus)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Mus musculus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL22,RPL22L1 [cytosol] (Mus musculus)
        
        Rpl22l1 [cytosol] (Mus musculus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL22,RPL22L1 [cytosol] (Mus musculus)
        
        Rpl22l1 [cytosol] (Mus musculus)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Mus musculus)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Mus musculus)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL22,RPL22L1 [cytosol] (Mus musculus)
        
        Rpl22l1 [cytosol] (Mus musculus)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL22,RPL22L1 [cytosol] (Mus musculus)
        
        Rpl22l1 [cytosol] (Mus musculus)
- rRNA processing (Mus musculus)
  - rRNA processing in the nucleus and cytosol (Mus musculus)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Mus musculus)
      - 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL22,RPL22L1 [cytosol] (Mus musculus)
        
        Rpl22l1 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9D7S7 Rpl22l1

Gene Names

Rpl22l1

Chain

chain:1-122

Reference Genes

BioGPS Gene:68028 Rpl22l1

KEGG:mmu:68028 Rpl22l1

Monarch:68028 Rpl22l1

NCBI Gene:68028 Rpl22l1

UCSC:Q9D7S7 Rpl22l1

Reference Transcript

Other Identifiers

10491191

10528474

1417126_a_at

17396498

4338335

4603205

4818655

4920198

4999608

5014637

5063719

5203207

5341311

5358655

5378786

5547545

68028

93987_f_at

A_51_P218814

A_52_P65897

A_55_P2159026

GO:0002181

GO:0003723

GO:0003735

GO:0005198

GO:0005829

GO:0005840

GO:0006412

GO:1990904

ILMN_2678755

aa285837_f_at

mMC019233

Participates

as a member of

Rpl22, Rpl22l1 [cytosol] (Mus musculus)

as a candidate of

RPL22,RPL22L1 [cytosol] (Mus musculus)

Inferred From

RPL22L1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_080793.1, NP_001334155.1

ENSEMBL

ENSMUSP00000043111, ENSMUST00000043867, ENSMUST00000194649, ENSMUSG00000039221, ENSMUSP00000141510

PRO

Q9D7S7

MGI

1915278

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