Reactome | Rps28 [cytosol]

Rps28 [cytosol]

Stable Identifier

R-MMU-9633550

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

40S ribosomal protein S28, RS28_MOUSE

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Mus musculus)

- Nonsense-Mediated Decay (NMD) (Mus musculus)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Mus musculus)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Mus musculus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        Rps28 [cytosol] (Mus musculus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        Rps28 [cytosol] (Mus musculus)
    - SMG6 hydrolyzes mRNA with premature termination codon (Mus musculus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        Rps28 [cytosol] (Mus musculus)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Mus musculus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        Rps28 [cytosol] (Mus musculus)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        Rps28 [cytosol] (Mus musculus)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Mus musculus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        Rps28 [cytosol] (Mus musculus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        Rps28 [cytosol] (Mus musculus)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Mus musculus)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Mus musculus)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        Rps28 [cytosol] (Mus musculus)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        Rps28 [cytosol] (Mus musculus)
- rRNA processing (Mus musculus)
  - rRNA processing in the nucleus and cytosol (Mus musculus)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Mus musculus)
      - 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        Rps28 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:P62858 Rps28

Gene Names

Rps28

Chain

chain:1-69

Reference Genes

BioGPS Gene:54127 Rps28

KEGG:mmu:54127 Rps28

Monarch:54127 Rps28

NCBI Gene:54127 Rps28

UCSC:P62858 Rps28

Other Identifiers

100758_at

10406024

10450050

10479809

10516479

10524415

10526215

10539700

1423763_x_at

1451101_a_at

1454778_x_at

17343643

4361387

4459633

4489100

4492295

4544227

4574016

4685831

4700427

5014688

5112405

5196685

5280603

5283019

54127

5422386

5568686

5573083

5614951

98085_f_at

A_51_P335671

A_52_P232909

A_52_P55271

A_52_P682465

GO:0000028

GO:0002181

GO:0003735

GO:0005198

GO:0005634

GO:0005730

GO:0005737

GO:0005783

GO:0005791

GO:0005829

GO:0005840

GO:0006364

GO:0006412

GO:0022626

GO:0022627

GO:0030490

GO:0032040

GO:0042254

GO:0042274

GO:0045202

GO:0065003

GO:0098556

GO:0098793

GO:0098794

GO:0140236

GO:0140242

GO:1990904

ILMN_1260088

U11248_f_at

mMC021979

Participates

as a component of

Other forms of this molecule

Rps28 [nucleoplasm]

Inferred From

RPS28 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_058540.1, NP_001342313.1

ENSEMBL

ENSMUST00000173019, ENSMUST00000166693, ENSMUSP00000110013, ENSMUST00000173844, ENSMUSP00000134615, ENSMUSG00000067288, ENSMUSP00000133357, ENSMUSP00000133642, ENSMUST00000087342

PRO

P62858

MGI

1859516

PDB

7CPU, 7LS1, 7LS2, 7CPV

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